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Introduction: Obesity and overweight are prevalent within college students and represent a major health concern due to sedentary lifestyles and absence of exercise. This study was intended to ascertain the impact of discrete and combined aerobic and resistance training exercises on maximal oxygen uptake (VO2 max) and Body Mass Index (BMI) among overweight collegiate population.
Method: In this study, 30 male college students aged between 18 and 26 years, with a Body Mass Index (BMI) greater than 25 kg/m, were divided at random between three groups: Group 1 (n = 10) engaged in aerobic exercise, Group 2 (n = 10) engaged in resistance training, and Group 3 (n = 10) engaged in combined training regime. BMI was determined using the formula weight/height (kg/m), and maximal oxygen uptake (VO2 max) was measured using the Queen's College Step Test, both prior to and following the intervention. The efficacy of the interventions was assessed once the fourth week was over.
Result: An ANCOVA showed significant effects of intervention type on BMI and VO₂ Max. For BMI, the Combined group had the lowest post-intervention BMI, F(2, 25) = 10.29, p < .001, η = 0.04. VO₂ Max also showed a main effect, F(2, 25) = 61.85, p < .001, η = 0.01, with the Aerobic and Combined groups demonstrating the greatest improvements, underscoring the effectiveness of these interventions.
Conclusion: This study highlights that Combined and Aerobic interventions significantly improve BMI and VO₂ Max, with the Combined group showing the greatest BMI reduction and both Combined and Aerobic groups demonstrating enhanced VO₂ Max.
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http://dx.doi.org/10.1016/j.jbmt.2024.12.023 | DOI Listing |
EMBO J
September 2025
School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Insulin resistance is a heritable risk factor for many chronic diseases; however, the genetic drivers remain elusive. In seeking these, we performed genetic mapping of insulin sensitivity in 670 chow-fed Diversity Outbred in Australia (DOz) mice and identified a genome-wide significant locus (QTL) on chromosome 8 encompassing 17 defensin genes. By taking a systems genetics approach, we identified alpha-defensin 26 (Defa26) as the causal gene in this region.
View Article and Find Full Text PDFGeroscience
September 2025
Research Institute of the McGill University Health Centre, 2155 Guy Street, Suite 500, Montreal, QC, H3H 2R9, Canada.
Frailty, often linked to sarcopenia, involves reduced muscle strength and mass. While sarcopenia has multiple causes, impaired muscle protein synthesis may contribute. Leucine and resistance training (RT) are anabolic stimuli, but the long-term effects of leucine combined with RT in pre/frail older women remain unclear.
View Article and Find Full Text PDFCell Death Discov
September 2025
Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Ado-trastuzumab is considered a standard treatment for patients with HER2+ metastatic breast cancer (mBC). Current clinical practices do not reliably predict therapeutic outcomes for patients who are refractory to therapy. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and therapeutic resistance, and the use of lncRNAs as tumor biomarkers is becoming more common in other diseases.
View Article and Find Full Text PDFJ Hosp Infect
September 2025
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Tropical Infectious Diseases Unit, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
Background: Antimicrobial resistance (AMR) transmission is shaped by a complex interplay of health system factors, many of which remain underexplored or insufficiently addressed. This study investigates concrete systemic transmission drivers in hospitals and long-term care facilities (LTCFs) for older adults in Merseyside, UK.
Methods: Qualitative data were collected through semi-structured interviews with 37 purposively selected participants across hospitals, LTCFs, community settings, and ambulance services.
Int J Pharm
September 2025
CINBIO, Immunology Group, Universidade de Vigo 36310 Vigo, Spain; Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy with poor therapeutic outcomes due to its desmoplastic tumor microenvironment (TME), hindering drug and activated immune cell penetration. Cancer-associated fibroblasts (CAFs) are central in supporting tumor growth and forming a protective stroma. We propose a novel dual-therapy targeting the Hippo pathway and histone deacetylation, both involved in tumor progression, resistance, and stromal interactions, to overcome PDAC therapeutic resistance.
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