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Objectives: Since 1949, occlusal contact area (OCA) has been recognised as an indicator of masticatory performance (MP), but it required individual and laborious analog measurement. Today, a digital workflow could provide automatic quantification.
Objective: To find optimal parameters for a digital evaluation in terms of maximising correlation between OCA and MP.
Methods: MP was measured clinically by comminution of standardised test food by 41 participants (mean age = 29, n female = 28), including 18 patients with dentofacial deformities and 23 healthy subjects with normal occlusion. OCA was measured in the laboratory. After impression taking, gypsum casts were digitised (D2000, 3shape) and aligned in maximum intercuspidation (Geomagic Design X2022, 3D Systems). The maxilla was enlarged with surface offsets of 100, 150, 200, 250, 300, 350, 400, 800 and 2000 μm to simulate different interocclusal distances. OCA was identified at the mandible surface by intersection with the respective enlarged maxilla scan (3D surface area). OCA projection onto the occlusal plane (2D area) was also computed, resulting in a total of 18 different OCA evaluations per patient.
Results: MP was lower in patients with malocclusion than in individuals with normal occlusion (X50 mean 5.35 vs. 4.62). The 18 mean OCAs ranged from 11 to 852 mm. In subjects with normal occlusion, strong correlations were shown for interocclusal distances between 150 and 300 μm combined with 3D projection (r < -0.7). For patients with malocclusion, no significant correlations were identified.
Conclusions: OCA appears a suitable indicator of MP in individuals with normal occlusion, but not in patients with malocclusion, where other factors seem more determinant.
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http://dx.doi.org/10.1111/joor.14002 | DOI Listing |
J Thromb Haemost
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy. Electronic address:
Background: Caplacizumab, a humanized anti-von Willebrand Factor (VWF) Nanobody®, is employed for immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) treatment. Its binding to the VWF A1 domain sterically inhibits VWF interaction with platelet glycoprotein Ib (GPIb), counteracting microthrombosis and accelerating the normalization of the platelet count. In caplacizumab-treated iTTP patients with bleeding episodes, measuring platelet-dependent VWF activity (VWF activity) is crucial for monitoring treatment with VWF concentrates.
View Article and Find Full Text PDFSurv Ophthalmol
September 2025
Department of Ophthalmology, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang 261041, China.
Lipid metabolism plays a critical role in maintaining normal physiological functions and is strongly linked to the pathogenesis of ocular vascular diseases. This review examines how disorders of lipid metabolism drive progression in ocular vascular diseases, including diabetic retinopathy, age-related macular degeneration, retinal vascular occlusive diseases, and retinopathy of prematurity. These disorders are classified as a related group due to their common feature of impaired ocular vascularization.
View Article and Find Full Text PDFJ Ayurveda Integr Med
September 2025
Regional Ayurveda Research Institute, Poojappura, Thiruvananthapuram, Kerala, 695012, India; Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, New Delhi, India.
This case report is the description of a devastating illness, Progressive Bulbar Palsy (PBP) of a sixty-seven years old male patient. He presented with complaints of slurred speech, hearing impairment, generalised weakness of limbs, weakened grip to hold objects in hand, difficulty to walk with normal speed, frequent dizzy feeling while walking, severe fatigue, increased anger, heaviness of head, depression, anxiety, decreased memory and headache for 1 year. When he consulted conventional medicine, in Magnetic Resonance Imaging (MRI) of brain, only 'Partial empty sella' and age related mild cerebral atrophy was detected and the patient was diagnosed PBP clinically.
View Article and Find Full Text PDFJ Am Heart Assoc
September 2025
Division of Experimental Cardiology, Department of Cardiology Erasmus MC University Medical Center Rotterdam The Netherlands.
Background: Despite successful recanalization after endovascular thrombectomy, more than half of patients with acute ischemic stroke with large-vessel occlusions experience an unsatisfactory outcome. Incomplete microvascular reperfusion may contribute to it, but its occurrence remains debated, partly due to clinical observations of hyperperfusion after recanalization. This study investigates the relationship between ischemia duration, infarct development, microclot presence, and cerebral perfusion in a swine model of focal cerebral ischemia and reperfusion.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Background: To elucidate the therapeutic effects and underlying mechanisms of palmatine, a principal alkaloid derived from Coptis chinensis, on neuroinflammation in ischemic stroke rat models induced by middle cerebral artery occlusion (MCAO).
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