Risk of Malignancy Ranges and Category Percentage Assignment in Cytopathology Reporting Systems: Are They Useful Quality Assurance Indicators?

Acta Cytol

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.

Published: May 2025


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Article Abstract

Background: Quality assurance (QA) is essential in cytopathology to ensure diagnostic accuracy. Common QA methods include peer reviews, 10% random reviews, and benchmarking against published standards. Benchmarking, which compares institutional data on specimen category assignment and risk of malignancy (ROM) with published body site reviews, helps evaluate performance and identify areas of improvement. Cytopathology reporting systems for various body sites categorize specimens based on ROM estimates. The diagnostic categories and ROM estimates in non-gynecologic cytopathology systems can serve as quality metrics to improve practices and maintain high standards of patient care.

Summary: A well-developed QA system in cytology is crucial for ensuring diagnostic accuracy and minimizing errors. By using tools like secondary reviews, retrospective analyses, and structured reporting systems, laboratories can improve practices, detect errors, and maintain high standards of patient care.

Key Messages: The cytopathology reporting systems help provide categorical information that can guide clinicians, ensuring quality assurance (QA) and accuracy in diagnosis across various organ sites. Institutional data on category assignments and ROM can be compared with broader literature to assess accuracy and QA. Significant outliers in ROM for specific categories should trigger peer review and potential retraining to improve diagnostic accuracy.

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http://dx.doi.org/10.1159/000546228DOI Listing

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