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http://dx.doi.org/10.1164/rccm.202502-0344RL | DOI Listing |
J Appl Physiol (1985)
September 2025
Department of Human Physiology and Nutrition, William J. Hybl Sport Medicine and Performance Center, University of Colorado Colorado Springs, Colorado Springs, CO, USA.
Chronic exposure to high altitude leads to increases in hemoglobin mass (Hbmass), which may improve exercise performance and decrease acute mountain sickness (AMS) symptoms. We evaluated the influence of intravenous iron or erythropoietin (EPO) treatment on Hbmass, exercise performance, and AMS during a 14-day exposure to 3094 m. Thirty-nine participants (12F) completed the study conducted in Eugene, Oregon (sea level (SL), 130 m) and Leadville, Colorado (3094 m).
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Hepatobiliary and Pancreatic Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Pancreatic ductal adenocarcinoma (PDAC) remains a devastating malignancy characterized by profound lethality, aggressive local invasion, dismal prognosis, and significant resistance to existing therapies. Two critical biological features underpin the challenges in treating PDAC: extensive perineural invasion (PNI), the process by which cancer cells infiltrate and migrate along nerves, and a profoundly immunosuppressive, or "cold," tumor microenvironment (TME). PNI is not only a primary route for local tumor dissemination and recurrence but also a major contributor to the severe pain often experienced by patients.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
September 2025
Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Transcatheter aortic valve replacement (TAVR) is a commonly performed procedure for the treatment of severe aortic stenosis. While it is generally considered a low-risk procedure, one of the rare potentially life-threatening complications includes aortic dissection. We report the case of a 75-year-old immunocompromised female who presented 2 weeks post-TAVR with persistent and worsening dyspnea, intermittent chest pain, and hypoxia.
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
September 2025
Department of Clinical Sciences, 1060 William Moore Dr, North Carolina State University, Raleigh, NC, 27606, USA. Electronic address:
Background And Aims: The devastation caused by necrotizing enterocolitis (NEC) has continued to claim the lives of infants despite advances in neonatal medicine. To address the acute, and often severe, intestinal epithelial damage caused by NEC, therapeutics that directly target epithelial recovery and cellular regeneration processes are needed.
Methods: We investigated the capacity of a decellularized human placental extract (HPE) to prevent and enhance recovery from NEC-like injury using in vitro and in vivo models.
Sci Prog
September 2025
Hangzhou Kang Ming Information Technology Co., Ltd, Zhejiang, China.
ObjectiveIschemic stroke, resulting from the interruption of blood supply to the brain, leads to cerebral ischemia, hypoxia, and necrosis, and is a prevalent disease characterized by high incidence, mortality, and disability rates. This study investigates the protective effects of ischelium on cerebral ischemia-reperfusion injury in a rat model, along with the potential mechanisms of action.MethodsWe established a rat cerebral ischemia-reperfusion model and administered different doses of ischelium as intervention across treatment groups.
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