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Background: The congenital heart disease population can provide a unique set of challenges during pacemaker implant, including the necessity of transvenous leads in a young group of patients. In this case report we demonstrate how leadless pacemakers may be used as an option in patients with Fontan circulation.
Case Summary: We present two cases of novel use of the Abbott AVEIR™ leadless pacemaker, including the first reported in person trans-baffle delivery of this device and implantation into a single ventricle heart. Our cases are a 30-year-old male with single ventricle physiology and Fontan circulation, found incidentally to have complete heart block (CHB) and a 48-year-old female with a Fontan circulation who had CHB and a history of syncope. These cases demonstrate a variety of venous access routes and add to the existing data of leadless pacemaker implantation in single ventricle physiology. The very long battery life of these devices make them ideal for patients with difficult venous access with bradycardia pacing requirement with low pacing burden.
Discussion: Leadless pacemakers offer a valuable alternative to transvenous pacing leads for providing bradycardia pacing support in this patient population.
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http://dx.doi.org/10.1093/ehjcr/ytaf146 | DOI Listing |
Pediatr Cardiol
September 2025
Division of Cardiology, Children's National Hospital, 111 Michigan Ave, Washington, DC, 20010, USA.
Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate.
View Article and Find Full Text PDFBrain Behav Immun
September 2025
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: The proteome is a valuable resource for pinpointing therapeutic targets. Therefore, we conducted a proteome-wide Mendelian randomization (MR) study aimed at identifying potential protein markers and therapeutic targets for Anti-N-Methyl-D-Aspartate Receptor Encephalitis (NMDAR-E).
Methods: Protein quantitative trait loci (pQTLs) were obtained from seven published genome-wide association studies (GWASs) focusing on the plasma proteome, resulting in summary-level data for 734 circulating protein markers.
Cureus
August 2025
Ophthalmology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Dandy-Walker syndrome (DWS), also referred to as Dandy-Walker malformation, is a rare congenital developmental anomaly characterized by enlargement of the posterior fossa, dilatation of the fourth ventricle, and cerebellar hypoplasia with upward rotation. Retinoblastoma is the most common primary intraocular malignancy in children and typically presents in the pediatric age group, with leukocoria and strabismus being common early signs. Although DWS and retinoblastoma are individually rare, their simultaneous occurrence is exceptionally uncommon.
View Article and Find Full Text PDFEClinicalMedicine
October 2025
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, China.
Background: Paediatric patients who underwent surgery for mitral regurgitation (MR) have a high risk of recurrence or death; however, no prediction tool has been developed to risk-stratify this challenging subpopulation.
Methods: In this multicentre cohort study, paediatric patients undergoing surgery for congenital MR in Shanghai Children's Medical Center in January 1st, 2009-December 31st, 2022 were included for analysis while those had a combination with infective endocarditis, anomalous left coronary artery from the pulmonary artery, rheumatic valvular disease, connective tissue disease, or single ventricle were excluded. A Cox regression model predictive of the primary outcome (a composite of mortality or mitral valve [MV] re-operation) was derived and converted to a point-based risk score.
Radiology
September 2025
Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background MRI-derived arrhythmogenic substrate, including late gadolinium enhancement (LGE) and extracellular volume fraction (ECV), is indicative of sudden cardiac death (SCD) risk in nonischemic dilated cardiomyopathy (DCM). The relative prognostic value of LGE and ECV remains unclear. Purpose To evaluate the performance of LGE and T1 mapping in predicting SCD in patients with DCM and to explore clinical implementation.
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