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Background: This study identified the cross-sectional and 1-year predictors of both passive exposure to online interactions with strangers and active engagement in such interactions among adolescents, focusing on individual factors (sex, age, attention-deficit/hyperactivity disorder [ADHD] diagnosis, and impulsivity) and environmental factors (satisfaction with family and peer relationships).
Methods: The sample comprised 349 adolescents (176 with ADHD and 173 without) and their parents. At baseline, data on lifetime online interactions with strangers, impulsivity, and satisfaction with family and peer relationships were examined. One year later, 249 adolescents (71.3 % of the original sample) completed a follow-up survey on their experiences with online interactions with strangers during the preceding year. Logistic regression analyses were conducted to identify the cross-sectional and prospective predictors of such interactions.
Results: The results revealed that 26.9 % of adolescents experienced passive exposure to online interactions with strangers, whereas 16.5 % actively interacted with strangers online during the 1-year follow-up period. Multivariable logistic regression revealed that older age (p = 0.004) and lack of foresight and self-control (p = 0.043) cross-sectionally correlated with active engagement at baseline. Older age (p = 0.041) and baseline exposure to online interactions with strangers (p = 0.014) significantly predicted passive exposure at follow-up. Additionally, older age (p = 0.012), ADHD diagnosis (p = 0.005), lack of foresight and self-control (p = 0.032), and baseline active online interactions with strangers (p < 0.001) significantly predicted active engagement at follow-up.
Conclusion: These findings highlight multiple factors that prospectively predict such interactions.
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http://dx.doi.org/10.1016/j.jfma.2025.04.024 | DOI Listing |
Arch Toxicol
September 2025
Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
The transition from traditional animal-based approaches and assessments to New Approach Methodologies (NAMs) marks a scientific revolution in regulatory toxicology, with the potential of enhancing human and environmental protection. However, implementing the effective use of NAMs in regulatory toxicology has proven to be challenging, and so far, efforts to facilitate this change frequently focus on singular technical, psychological or economic inhibitors. This article takes a system-thinking approach to these challenges, a holistic framework for describing interactive relationships between the components of a system of interest.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Academy for Health Innovation Uganda, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Background: Sexually transmitted infections are a significant public health concern, particularly in sub-Saharan Africa, where their prevalence remains high. Promoting awareness and reducing stigma are essential strategies for addressing this challenge, but those affected often have limited access to accurate and culturally appropriate health information. Therefore, innovative solutions are essential to enhance sexual health literacy and encourage informed health-seeking behaviors.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Community Medicine, Faculty of Health, UiT The Arctic University of Norway, Tromsø, Norway.
Background: The ability to access and evaluate online health information is essential for young adults to manage their physical and mental well-being. With the growing integration of the internet, mobile technology, and social media, young adults (aged 18-30 years) are increasingly turning to digital platforms for health-related content. Despite this trend, there remains a lack of systematic insights into their specific behaviors, preferences, and needs when seeking health information online.
View Article and Find Full Text PDFPLoS One
September 2025
School of Social Sciences and Global Studies, The Open University, Milton Keynes, United Kingdom.
Background: There is evidence that cerebral palsy (CP) could be linked to stigma and discrimination, however current evidence is limited to small qualitative studies. The goal of this co-designed survey was to elicit information on experiences of stigma and discrimination amongst a larger sample of adults in the UK and Ireland.
Methods: Quantitative questions about sources of stigma and qualitative questions designed to elicit information on experiences of stigma were shared via an online survey.
Bioinformatics
September 2025
Department of Mathematical Sciences, The University of Texas at Dallas, TX United States.
Motivation: The advent of next-generation sequencing-based spatially resolved transcriptomics (SRT) techniques has reshaped genomic studies by enabling high-throughput gene expression profiling while preserving spatial and morphological context. Understanding gene functions and interactions in different spatial domains is crucial, as it can enhance our comprehension of biological mechanisms, such as cancer-immune interactions and cell differentiation in various regions. It is necessary to cluster tissue regions into distinct spatial domains and identify discriminating genes that elucidate the clustering result, referred to as spatial domain-specific discriminating genes (DGs).
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