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Article Abstract
Background: Early-phase F-18 FP-CIT PET/CT (PET) has been reported to possibly replace FDG PET/CT (PET) in the differential diagnosis of parkinsonism. We investigated the correlation between PET and PET to explore their potential interchangeability.
Method: Our retrospective study included 187 participants, categorized into Parkinson's disease (PD), atypical parkinsonian disorders (APD), and participants with intact dopamine transporters (DAT). We analyzed the correlation of standardized uptake value ratios (SUVR) from early-phase PET and PET scans across 23 different brain volumes-of-interest using Pearson's correlation analysis. We conducted this analysis for all participants collectively and then separately for each group.
Results: For all participants without grouping, a moderate correlation (with correlation coefficients R ranging from 0.360 in right putamen to 0.530 in left caudate nucleus) was observed between Early-phase PET and PET. PD group showed a weak to moderate correlation (0.226 in left frontal cortex ≤ R ≤ 0.555 in right cerebellum). APD group revealed a moderate correlation with R ranging from 0.488 in right cerebellum to 0.692 in right occipital cortex. Conversely, a lack of correlation in specific areas for DAT group indicated distinctions between the modalities.
Conclusions: Our study showed interchangeability with a moderate correlation between early-phase PET and PET. However, careful consideration is needed for DAT group.
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| http://dx.doi.org/10.1016/j.compbiomed.2025.110177 | DOI Listing |
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