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Objective: Stereotactic radiosurgery (SRS) is widely used for the treatment of intracranial dural arteriovenous fistulas (DAVFs); however, the outcomes of repeated SRS to deal with residual DAVFs are unclear. This study assessed the benefits and potential negative consequences of repeated SRS in patients with residual DAVFs.
Methods: This retrospective study examined all patients who underwent two SRS procedures for DAVFs in a single academic medical center between January 1998 and December 2022. Information related to patient demography, DAVFs characteristics, and clinical outcomes were obtained from medical records. The objective in this study was to obtain a preliminary overview of the results of repeated SRS for DAVFs.
Results: The study cohort of 19 patients included 14 patients with non-cavernous sinus (NCS) DAVFs and 5 patients with cavernous sinus (CS) DAVFs. The NCS group included 8 patients who were categorized as low-grade (Borden grade 1) and 6 as high-grade (Borden grade 2 or 3). The median follow up duration after the second session of SRS was 37 months. Symptomatic improvement was noted in 16 patients (84.2%) and total obliteration was identified in 11 patients (57.9%). No patient suffered from intracranial hemorrhage after the repeated SRS. One patient (5.3%) experienced symptomatic radiation-induced change mandating temporary course of medical treatment.
Conclusions: Repeated SRS appears to be a safe and effective approach to deal with residual DAVFs, resulting in symptomatic improvement and complete radiologic obliteration.
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http://dx.doi.org/10.1007/s00701-025-06536-1 | DOI Listing |
BMC Psychol
August 2025
Blood Center of Zhejiang Province, 789 Jianye Road Binjiang District, Hangzhou City, Zhejiang Province, China.
The current study aimed to develop and validate a self-reinforcement scale for repeated blood donation (SRS-RBD). In Study 1, six items were created, and the factor structure of SRS-RBD was explored among 155 Chinese student blood donors. In Study 2, SRS-RBD was validated among 164 donors.
View Article and Find Full Text PDFJ Appl Clin Med Phys
September 2025
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background: Lack of an ideal detector for small field dosimetry has led to the development of many new types of detectors. Recent studies have shown that plastic scintillation detectors (PSDs) provide favorable dosimetric characteristics, such as minimal volume averaging and fluence perturbation effects, real time response rates, high signal to noise ratio (SNR), and independence to temperature, energy spectrum, dose rate, and irradiation direction, in the field of small field dosimetry, largely due to their small size and water-equivalent composition materials, which eliminates the need for certain correction factors.
Purpose: The goal of this study was to evaluate a new 0.
J Neurooncol
August 2025
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Background And Objectives: Atypical and anaplastic meningioma (World Health organization [WHO] Grades II and III) present therapeutic challenges due to their aggressive behavior and high risk of recurrence. This study addressed the lack of data related to the effectiveness and safety of repeated stereotactic radiosurgery (SRS) in managing high-grade recurrent or residual meningioma.
Methods: This study analyzed data extracted from the medical records of 112 patients (mean age of 57.
bioRxiv
August 2025
Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Image-based phenotypic screening has emerged as a powerful tool for revealing single-cell heterogeneity and dynamic phenotypic responses in preclinical drug discovery. Compared to traditional static end-point assays, live-cell longitudinal imaging captures the temporal trajectories of individual cells, including transient morphological adaptations, motility shifts, and divergent subpopulation behaviors, enabling high content features and more robust early prediction of treatment outcomes. Fluorescence-based screening, while highly specific, is constrained in live-cell contexts by broad spectral overlaps (limiting multiplexing to fewer than six channels), bulky fluorophores that may perturb small-molecule interactions, and photobleaching or phototoxicity under repeated excitation.
View Article and Find Full Text PDFJ Neurooncol
October 2025
Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Objectives: To characterize the outcomes of patients with brain metastases located in the motor cortex after stereotactic radiosurgery (SRS).
Methods: A retrospective review was performed of 1151 patients with brain metastases who underwent Gamma Knife SRS between 2012 and 2020. Outcome measures were motor function, radiographic changes, adverse radiation effect (ARE), disease-free progression, and overall survival time.