Publications by authors named "Eishan Ashwat"
Early Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Implantation.
Ann Thorac Surg
August 2025
Background: This study aimed to elucidate the incidence, risk factors, and midterm outcomes associated with hemodynamic valve deterioration (HVD) 1 year after transcatheter aortic valve implantation (TAVI).
Methods: This was a retrospective, single-institution cohort study of consecutive TAVIs from 2012 to 2022. Patients with immediate post-TAVI, 30-day, and 1-year echocardiographic data were included.
Objectives: To characterize the outcomes of patients with brain metastases located in the motor cortex after stereotactic radiosurgery (SRS).
Methods: A retrospective review was performed of 1151 patients with brain metastases who underwent Gamma Knife SRS between 2012 and 2020. Outcome measures were motor function, radiographic changes, adverse radiation effect (ARE), disease-free progression, and overall survival time.
Objective: This study sought to determine the impact of surgical versus transcatheter aortic valve replacement in patients with low-flow, low-gradient aortic stenosis.
Methods: This was an observational study of consecutive aortic valve replacements for severe aortic stenosis from 2010 to 2023. Patients with low-flow, low-gradient aortic stenosis (aortic valve mean gradient <40 mm Hg and a stroke volume index <35 mL/m) were included.
The current state of transcatheter aortic valve replacement explant: an updated systematic review.
Ann Cardiothorac Surg
March 2025
Background: Despite ever-growing adoption of transcatheter aortic valve replacement (TAVR) in younger healthier patients, a limited number of studies have described post-TAVR valve reinterventions such as surgical explantation known as "TAVR explant".
Methods: We performed a systematic review to characterize the current state of TAVR explant in patients with a failing transcatheter heart valve (THV) using data published by April 30, 2024 in compliance with the PRISMA and MOOSE reporting guidelines. The protocol was registered in PROSPERO (CRD42024529188).
Background: Paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. Mild PVL remains prevalent after TAVI, and its impact on long-term survival is unclear. This study aimed to examine the incidence, impact on survival, and progression of PVL.
View Article and Find Full Text PDFPost-Liver Transplant Outcomes: A Comparative Study of 6 Predictive Models.
Transplant Direct
December 2024
Background: We compared the performance of the Liver Transplant Risk Score (LTRS) with the survival outcomes following liver transplantation (SOFT), pretransplant SOFT (P-SOFT), Balance of Risk Score (BAR), donor-age and model for end-stage liver disease (D-MELD), and Organ Procurement and Transplantation Network Risk Prediction Score (ORPS) for the prediction of 90-d mortality, 1-y mortality, and 5-y survival after first-time liver transplantation (LT).
Methods: A retrospective analysis of the Scientific Registry of Transplant Recipients was conducted using data collected between 2002 and 2021.
Results: A total of 82 696 adult LT recipients with a median age of 56 y were included.
Article Synopsis
- - Significant progress has been made in diagnosing and treating cholangiocarcinoma (CC), a serious liver cancer making up 15% of primary liver tumors, though it still accounts for 2% of cancer-related deaths due to its complexity and challenges.
- - Key risk factors include chronic inflammation, genetics, and congenital issues, with CC categorized into intrahepatic and extrahepatic types, both of which have been increasing in incidence over the past two decades.
- - Advancements in imaging, molecular profiling, and the evolution of endoscopic techniques have improved early detection and treatment, while multidisciplinary teams enhance patient care through combined surgical, medical, and palliative approaches.
Article Synopsis
- The study compares outcomes of bioprosthetic versus mechanical valves in older patients who had surgical aortic valve replacement (SAVR), using data from 1,847 patients over a follow-up period of 6.2 years.
- It found no significant differences in early survival between valve types across age groups, but younger patients (<65 years) with bioprosthetic valves faced higher reintervention rates compared to those with mechanical valves.
- The study indicates that bioprosthetic valves are associated with a significantly higher risk of needing repeat aortic valve surgery in younger patients, highlighting the need for better validation of valve type recommendations for different age groups.
Acute aortic dissection (AAD) is a rare and potentially fatal complication associated with transcatheter aortic valve replacement (TAVR). Owing to the paucity of existing institutional data, we sought to assess the incidence of postimplant AAD in patients who underwent TAVR at a single institution. All patients who underwent TAVR from 2013 to 2022 were retrospectively reviewed to identify those who possessed clinical or radiologic evidence of AAD after TAVR.
View Article and Find Full Text PDFImmune checkpoint inhibition has shown success in treating metastatic cutaneous melanoma but has limited efficacy against metastatic uveal melanoma, a rare variant arising from the immune privileged eye. To better understand this resistance, we comprehensively profile 100 human uveal melanoma metastases using clinicogenomics, transcriptomics, and tumor infiltrating lymphocyte potency assessment. We find that over half of these metastases harbor tumor infiltrating lymphocytes with potent autologous tumor specificity, despite low mutational burden and resistance to prior immunotherapies.
View Article and Find Full Text PDFIntroduction: We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance.
Methods: The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included.
Article Synopsis
- The study aimed to compare the clinical outcomes between radial artery (RA) and right internal mammary artery (RIMA) grafts used in coronary artery bypass grafting (CABG) over the years 2010-2022.
- A total of 1,674 patients who had multiarterial CABG were analyzed, with 323 patients in each graft group after matching for baseline characteristics.
- The findings indicated no significant differences in immediate postoperative outcomes or long-term survival; however, the RA group showed a higher trend for major adverse cardiac and cerebrovascular events (MACCE) and repeat revascularization after five years compared to the RIMA group.
Article Synopsis
- Multiarterial grafting has advantages, but saphenous vein (SV) grafts are still more commonly used in coronary artery bypass grafting (CABG) despite unclear benefits of radial artery (RA) grafts.
- A study analyzed outcomes from 8,774 CABG patients between 2010 and 2022, comparing those with RA grafts to those with SV grafts, using propensity score matching to balance the cohorts.
- The findings showed no significant difference in immediate complications or long-term survival between the graft types, but patients with SV had a higher rate of freedom from major adverse cardiac and cerebrovascular events (MACCE).
Background And Aims: Many centers do not offer living donor transplants for patients in need of a liver retransplant. We aimed to study our liver retransplant outcomes using living donors and compared them with those of retransplants performed using deceased donors.
Methods: This study retrospectively analyzed all retransplants performed at our center between 2009 and 2023, and outcomes of living donor retransplants were compared with deceased donor retransplants using standard statistical tests.
Current Status of Living Donor Liver Transplantation: Impact, Advantages, and Challenges.
Curr Gastroenterol Rep
October 2023
Purpose Of This Review: This review provides an overview of the current status of Living Donor Liver Transplant (LDLT). It discusses the impact of LDLT on waitlist and post-transplantation outcomes, highlighting the technical challenges and unique advantages of LDLT.
Recent Findings: Recent findings show that LDLT offers several theoretical advantages over deceased donor liver transplant, including shorter wait times, better graft quality, and improved post-transplant outcomes.
Background/purpose: Neoadjuvant chemotherapy (NAC) is gaining popularity over a surgery-first (SF) approach in treating resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC). However, what constitutes effective neoadjuvant chemotherapy is unknown.
Methods: We retrospectively analyzed resectable and borderline resectable PDAC patients who underwent pancreaticoduodenectomy (2010-2019) at a single institution.
Background: High kidney-donor profile index (KDPI) kidneys have a shorter survival than grafts with lower KDPI values. It is still unclear, however, whether their shorter longevity depends on an inferior baseline function, faster functional decline, or the combination of both.
Methods: We analyzed the estimated glomerular filtration rate (eGFR) of 605 consecutive recipients of deceased donor kidney transplants (KT) at 1, 3, 6, 12, 18, 24, 36, 48, and 60 months.
Background: We analyzed the outcomes of patients with hepatic epithelioid hemangioendothelioma (HEHE) in the United States after stratification by their most definitive treatment.
Methods: The National Cancer Data Base was used to identify patients with HEHE between 2004 and 2018. Patients were divided in four treatment groups: no surgical therapy, ablation, liver resection or liver transplantation.