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Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility and bio-degradability reduce damage to healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules are particularly useful in targeted drug delivery within malignant cells. This article reviews recent progress of PAMAM in imaging and treating breast cancer, lung cancer, hepatocellular cancer, colorectal cancer, gastric cancer, prostate cancer, and glioblastoma. This review aims to provide new and feasible ideas for cancer diagnosis imaging and treatment while also serving as a significant reference point for personalized tumor therapy based on PAMAM materials.
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http://dx.doi.org/10.1080/09205063.2025.2497623 | DOI Listing |
Int J Pharm
October 2025
NICM Health Research Institute, Western Sydney University, Westmead, Australia. Electronic address:
Liver fibrosis is a progressive condition characterized by excessive accumulation of extracellular matrix components, which impairs liver function and can lead to cirrhosis or hepatocellular carcinoma. In this study, we designed a multifunctional poly(amidoamine) dendrimer-based gene delivery system (VA/CLU/COL-P@mp) to target activated hepatic stellate cells (aHSCs) and mitgate liver fibrosis. This platform leverages clusterin (CLU) for Kupffer cell evasion, collagenase I (COL) to enhance nanoparticle penetration through fibrotic ECM, and vitamin A for targeted binding to retinol-binding protein (RBP) receptors on aHSCs.
View Article and Find Full Text PDFJ Nanobiotechnology
August 2025
Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background: Osteoarthritis (OA) represents a major global health challenge, characterized by progressive cartilage degeneration and subchondral bone remodeling, which culminate in debilitating pain and functional impairment. While recent studies have underscored the pivotal role of activated osteoclasts in the pathogenesis of OA and its associated pain, the therapeutic potential of intra-articular drug delivery has been hindered by challenges such as rapid synovial clearance and the poor permeability of cartilage, limiting the effective inhibition of subchondral osteoclast activity.
Methods: Sixth generation polyamidoamine (PAMAM) dendrimers were used to delivery pamidronate disodium (PD) penetrating cartilage (PD@PM).
Recent years have witnessed the gradual use of dendrimers to prepare and modify various separation materials, including adsorbents and chromatographic stationary phases. Polyamide-amine (PAMAM) has become one of the most widely used dendritic materials because it is simple to prepare, inexpensive, hypotoxic, and has excellent performance characteristics. PAMAM is advantageous as a modification material for adsorbents and chromatographic stationary phases compared to other traditional materials.
View Article and Find Full Text PDFJ Biomater Sci Polym Ed
August 2025
Key Laboratory of Research on Human Genetic Diseases at Universities of Inner Mongolia Autonomous Region, Chifeng University, Inner Mongolia, China.
Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility and bio-degradability reduce damage to healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules are particularly useful in targeted drug delivery within malignant cells.
View Article and Find Full Text PDFACS Appl Mater Interfaces
April 2025
Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.
Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked polyamidoamine (PAMAM) dendrimer nanoparticles.
View Article and Find Full Text PDF