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http://dx.doi.org/10.1714/4488.44883 | DOI Listing |
J Control Release
August 2025
The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala University BMC, P.O Box 580, Uppsala 751 23, Sweden. Electronic address:
Oral delivery of therapeutic peptides is limited by degradation by digestive proteases and poor gastrointestinal permeability. We have investigated how physicochemical properties, including degree of lipidation and degree of amino acid sequence modification, along with formulation with a permeation enhancer (PE), influence the enzymatic stability and intestinal absorption of glucagon-like peptide-1(GLP-1) receptor agonists. We compared four peptides: J211 (non-lipidated; modified), J229 (mono-lipidated; modified), MEDI7219 (bis-lipidated; modified), and semaglutide (mono-lipidated control; least modified).
View Article and Find Full Text PDFIntern Med
August 2025
Department of Cardiology, Kanazawa University Graduate School of Medicine, Japan.
We present the case of a woman with heterozygous familial hypercholesterolemia with a history of myocardial infarction at 53 years of age. Her initial low-density lipoprotein (LDL) cholesterol level was 312 mg/dL, which was reduced to ~50 mg/dL using statins, ezetimibe, and evolocumab. However, the patient also had diabetes, and its management gradually worsened.
View Article and Find Full Text PDFMed Clin (Barc)
August 2025
Servicio de Endocrinología y Nutrición, Hospital HM Madrid Río, HM hospitales, Instituto de Investigación Sanitaria HM Hospitales, Spain.
Obesity is a chronic and relapsing disease associated with medical complications and mortality. Our improved understanding of the relevance of the gut-brain axis in regulating appetite and body weight has encouraged research into nutrient-stimulated gastroenteropancreatic hormones as a new therapeutic arsenal for the treatment of people living with obesity. Beyond the necessary lifestyle changes, this new era with second-generation drugs has been able to achieve weight loss of 15-25%, close to that of bariatric surgery.
View Article and Find Full Text PDFDiabetol Metab Syndr
August 2025
Department of Pharmacy, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong Province, China.
Introduction: The management of type 2 diabetes not only requires effective medications to regulate blood glucose levels, but also needs to consider the economic implications. Liraglutide, dulaglutide, and semaglutide, three widely-used glucagon-like peptide-1 receptor agonists, have shown significant efficacy in diabetes treatment. This review aimed to systematically assess the cost-effectiveness of liraglutide in comparison to dulaglutide or oral semaglutide for treating type 2 diabetes.
View Article and Find Full Text PDFCureus
July 2025
Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
Congenital linear scleroderma (CLS) is a rare connective tissue disorder characterized by unilateral linear induration that can lead to restricted mobility and limb deformities. Various treatments have been proposed, including D-penicillamine, phototherapy, oral vitamin D, and immunosuppressants such as methotrexate (MTX), cyclosporine, and interleukin-6 (IL-6) inhibitors. We present the case of a 14-year-old female patient with refractory CLS, whose condition continued to worsen despite treatment with tocilizumab, mycophenolate mofetil (MMF), and MTX.
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