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Background and ObjectivesProsthetic hand development is undergoing a transformative phase, blending biomimicry and neural interface technologies to redefine functionality and sensory feedback. This article explores the symbiotic relationship between biomimetic design principles and neural interface technology (NIT) in advancing prosthetic hand capabilities.MethodsDrawing inspiration from biological systems, researchers aim to replicate the intricate movements and capabilities of the human hand through innovative prosthetic designs. Central to this endeavor is NIT, facilitating seamless communication between artificial devices and the human nervous system. Recent advances in fabrication methods have propelled brain-computer interfaces, enabling precise control of prosthetic hands by decoding neural activity.ResultsAnatomical complexities of the human hand underscore the importance of understanding biomechanics, neuroanatomy, and control mechanisms for crafting effective prosthetic solutions. Furthermore, achieving the goal of a fully functional cyborg hand necessitates a multidisciplinary approach and biomimetic design to replicate the body's inherent capabilities. By incorporating the expertise of clinicians, tissue engineers, bioengineers, electronic and data scientists, the next generation of the implantable devices is not only anatomically and biomechanically accurate but also offer intuitive control, sensory feedback, and proprioception, thereby pushing the boundaries of current prosthetic technology.ConclusionBy integrating machine learning algorithms, biomechatronic principles, and advanced surgical techniques, prosthetic hands can achieve real-time control while restoring tactile sensation and proprioception. This manuscript contributes novel approaches to prosthetic hand development, with potential implications for enhancing the functionality, durability, and safety of the prosthetic limb.
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http://dx.doi.org/10.1177/15459683251331593 | DOI Listing |
J Neurosurg
September 2025
1Division of Hand and Microvascular Surgery, Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Objective: The role of amputation and myoelectric prosthetic fitting for hand function in traumatic pan-brachial plexus injury (pBPI) continues to evolve. This study evaluated the function and activity performance of patients with traumatic pBPI who underwent amputation and prosthetic fitting with a myoelectric prosthesis (MEP) for hand function.
Methods: A retrospective analysis of adult patients who underwent elective amputation after sustaining a pBPI followed by MEP for hand function was performed.
Biol Cybern
September 2025
Department of Electrical Engineering, Bahria University, H-11, 44000, Islamabad, Pakistan.
The dexterity of the human hand is largely due to its multiple degrees of freedom. However, coordinating the movements of the ring and little fingers independently can be challenging because of the biomechanical and neurological interdependencies between them. This research presents a cascade control system based on fuzzy logic to manage the dynamic movements of these fingers within a simulated biomechanical model of a human hand.
View Article and Find Full Text PDFCan Prosthet Orthot J
August 2025
Department of Rehabilitation Science and Technology, University of Pittsburgh, USA.
Background: Increasing balance and stability, along with efficient locomotion, is a high-priority goal of physical rehabilitation after limb loss in order to facilitate effective participation in society. Research in the general population suggests that the ability to walk fast is correlated to good performance in balance tests. However, it is unclear if and how prosthesis use influences this correlation.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
September 2025
Limb loss affects millions globally, impairing physical function and reducing quality of life. Most traditional surface electromyographic (sEMG) and semi-autonomous methods require users to generate myoelectric signals for each control, imposing physically and mentally taxing demands. This study aims to develop a fully autonomous control system that enables a prosthetic hand to automatically grasp and release objects of various shapes using only a camera attached to the wrist.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Objective: To investigate the short- and mid-term clinical efficacy of denosumab combined with 3D-printed prosthesis in the treatment of patients with giant cell tumor of the distal radius.
Methods: From January 2016 to January 2022, 20 patients with giant cell tumor of the distal radius underwent denosumab treatment combined with 3D-printed prosthetic reconstruction at our hospital. This study evaluates the short- and mid-term efficacy by analyzing clinical cases where denosumab was used preoperatively, followed by 3D-printed biological prosthesis reconstruction of the distal radius tumor segment defect.