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Introduction: The timing of post-operative discharge following colectomy procedures remains a subject of debate among colorectal surgeons. Prior studies have demonstrated the safety and adoption of early discharge within 24 h after elective colectomy in carefully selected patients.
Methods: This retrospective cohort study utilizing data from the American COllege of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) from 2012 to 2021. Adult patients undergoing elective partial colectomy with primary anastomosis and documented length of stay were included. Patients were stratified into early (< 24) and non early (≥24 h) discharge groups. Propensity score matching was used to control for baseline demographics and non-modifiable risk factors. Primary outcomes included 30-day readmission rates and adoption trends of early discharge over time.
Results: A total of 282,037 patients met inclusion criteria of which 6364 (2.3%) were discharged within 24 h. On propensity score matching the early discharge cohort had a statistically significantly lower rate of readmission (5.5% versus 7.3%, P < 0.001). Additionally, the early discharge group had a significantly reduced rate of anastomotic leak (1.0 versus 2.6%), ileus (2.0% versus 7.6%), and rate of reoperation (1.2% versus 4.0%) (P < 0.001). The proportion of early discharge colectomies increased from 0.8% in 2012 to 3.6% in 2021 (P < 0.001).
Conclusions: In carefully selected patients, early discharge after colectomy with primary anastomosis does not increase the risk of readmission, reoperation, or 30-d complication rates. Furthermore, the increasing trend in utilization of early discharge after colectomy suggests an increasing acceptance of this practice, though it remains a minority of all colectomies performed among institutions participating in ACS-NSQIP.
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http://dx.doi.org/10.1016/j.jss.2025.03.021 | DOI Listing |
Surg Endosc
September 2025
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Background: Surgical resection is the cornerstone for early-stage non-small cell lung cancer (NSCLC), with lobectomy historically standard. Evolving techniques have spurred debate comparing lobectomy and segmentectomy. This study analyzed early postoperative patient-reported symptoms and functional status in patients with early NSCLC undergoing either procedure.
View Article and Find Full Text PDFJ Neural Eng
September 2025
University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104-6243, UNITED STATES.
New implantable and wearable devices hold great promise to help patients manage their seizure disorders. One proposed application is measuring the rate of interictal epileptiform discharges as a biomarker of medication levels and seizure risk. This study aims to determine whether interictal epileptiform spike rates (spikes) are independently associated with anti-seizure medication (ASM) levels and evaluate whether spike rates are a reliable biomarker for ASM levels.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Introduction: Duodenal injuries occur in significant number of patients after abdominal trauma. Though most, 75 %, occur after penetrating mechanism of injury the remaining occur after blunt trauma and these are the commonly missed cases unless high index of suspicion is maintained. Here we presented a case of isolated retroperitoneal duodenal perforation after blunt abdominal trauma with a delayed diagnosis and management.
View Article and Find Full Text PDFPLoS One
September 2025
Satellite Collections North, Genebank Department, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Malchow/Poel, Germany.
Treatment of seeds with cold atmospheric pressure plasma (CAPP) is in its proof-of-concept phase with regard to its effect on germination and plant growth. To increase the germination of hardseeded red clover (Trifolium pratense L.), seeds are usually scarified, which is time-consuming and labour-intensive.
View Article and Find Full Text PDFJ Clin Invest
September 2025
The University of Texas at Austin, Austin, United States of America.
Background: Following SARS-CoV-2 infection, ~10-35% of COVID-19 patients experience long COVID (LC), in which debilitating symptoms persist for at least three months. Elucidating biologic underpinnings of LC could identify therapeutic opportunities.
Methods: We utilized machine learning methods on biologic analytes provided over 12-months after hospital discharge from >500 COVID-19 patients in the IMPACC cohort to identify a multi-omics "recovery factor", trained on patient-reported physical function survey scores.