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Functional training is increasingly recognized for its potential to improve physical function and quality of life (QoL) in older adults. This randomized controlled trial examined the effects of a six-week functional training program on physical function, cardiorespiratory fitness, and QoL in older women. Fifty older women (mean age: 63.5 ± 3.7 years) were randomly assigned to a functional training group ( = 25) or a control group ( = 25). The intervention group participated in a six-week functional training program (six sessions per week), while the control group maintained usual daily activities. Outcomes included dynamic balance (TUG test), flexibility, muscle strength, walking speed, cardiorespiratory fitness (two-minute step test), and QoL. Functional training significantly improved dynamic balance, lower body flexibility, lower body strength, walking speed, and aerobic endurance ( < .05 for all). QoL significantly increased in the functional training group across all domains, as well as overall scores ( < .05). However, the control group experienced declines in some measures. Functional training is a safe and effective intervention for improving physical function, cardiorespiratory fitness, and QoL in older women. The significant enhancements in physical and mental health highlight its value in promoting independence and well-being in aging populations. Future studies should explore its long-term benefits and scalability.
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http://dx.doi.org/10.1177/10998004251337063 | DOI Listing |
Adv Sci (Weinh)
September 2025
Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.
Circulating tumor cells (CTCs) carry intact tumor molecular information, making them invaluable for personalized cancer monitoring. However, conventional capture methods, relying on passive diffusion, suffer from low efficiency due to insufficient collision frequency, severely limiting clinical utility. Herein, a magnetic micromotor-functionalized DNA-array hunter (MMDA hunter) is developed by integrating enzyme-propelled micromotors, magnetic nanoparticles, and nucleic acid aptamers into distinct functional partitions of a DNA tile self-assembly structure.
View Article and Find Full Text PDFESC Heart Fail
September 2025
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Heart failure (HF) is a multifactorial and pathophysiological complex syndrome, involving not only neurohormonal activation but also oxidative stress, chronic low-grade inflammation, and metabolic derangements. Central to the cellular defence against oxidative damage is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that orchestrates antioxidant and cytoprotective responses. Preclinical in vitro and in vivo studies reveal that Nrf2 signalling is consistently impaired in HF, contributing to the progression of myocardial dysfunction.
View Article and Find Full Text PDFNeuropsychol Dev Cogn B Aging Neuropsychol Cogn
September 2025
Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cognitive function is a critical health indicator of older adults in later life. However, previous research has paid less attention to the impact of pre-retirement work-related characteristics on cognitive functions, especially in Asia. Thus, this study aims to examine the relationship between work-related factors and cognitive functions of the retired population, using Taiwan as an example.
View Article and Find Full Text PDFAnn Geriatr Med Res
September 2025
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Background: Poor hand dexterity may increase the risk of functional disability; however, few studies have examined the relationship between hand dexterity and incident functional disability. The aim of this study was to prospectively investigate the dose-response association of hand dexterity with incident functional disability in community-dwelling older adults.
Methods: This study included 1,069 older adults aged ≥65 years in Kasama City, Japan.
Analyst
September 2025
Functional Nanomaterial-based Chemical and Biological Sensing Technology Innovation Team of Department of Education of Yunnan Province, Yunnan Minzu University, Kunming 650504, P. R. China.
Copper ions are essential elements in the human body and participate in various physiological activities in the bodies of organisms. Herein, an ultrasensitive electrochemical biosensor was developed for detection of copper ions (Cu) based on FeO@Au magnetic nanoparticles (FeO@Au MNPs) and a Cu-dependent DNAzyme assisted nicking endonuclease signal amplification (NESA) strategy. dsDNA is formed by a hybridization reaction between DNA S2 and S1 immobilized on the surface of FeO@Au MNPs.
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