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Background: Heterotopic heart transplantation is a surgical technique that has not been embraced broadly. In this historic technique, the donor heart is sutured in parallel to the recipient heart with both hearts in place.
Case Summary: We report a patient who received a heterotopic heart transplant at our institution more than 15 years ago with preserved cardiac function and who needed a myocardial biopsy due to heart failure symptoms. Due to complex anatomy, a cardiac computed tomography imaging reconstruction was used to create a live roadmap overlay on fluoroscopy during myocardial biopsy. Such a technique facilitated obtaining a biopsy successfully and safely to rule out rejection.
Discussion: Heterotopic heart transplantation is a surgical procedure that has a potential physiologic and immunologic advantage in select patients needing a heart transplant. Utilizing imaging guidance for navigating complex anatomy to perform a myocardial biopsy can have potential applications in providing safe and increasing yield in patchy diseases of the heart.
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http://dx.doi.org/10.1016/j.jhlto.2025.100259 | DOI Listing |
JACC Cardiovasc Interv
August 2025
Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Centro de Investigación Biomédica En Red - Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.
Background: Caval valve implantation is currently the only alternative for patients with severe tricuspid regurgitation (TR) who are deemed unsuitable candidates for transcatheter orthotopic therapies.
Objectives: The aim of this study was to assess the efficacy and safety of TricValve system at 1-year follow-up.
Methods: TricBicaval registry is a multicenter registry that retrospectively enrolled all consecutive patients with severe TR treated with TricValve system.
Orv Hetil
August 2025
1 Gottsegen György Országos Kardiovaszkuláris Intézet Budapest, Haller u. 29., 1096 Magyarország.
Severe, symptomatic tricuspid regurgitation is a progressive disease with poor prognosis and limited treatment options. TricValve (bicaval, heterotopic valve system) implantation is a new palliative treatment option. The stented bioprosthesis are implanted in the inferior and superior caval veins without interveniening with the native tricuspid valve.
View Article and Find Full Text PDFBraz J Cardiovasc Surg
July 2025
Centro de Engenharia em Assistência Circulatória, Instituto Dante Pazzanese de Cardiologia, São Paulo, São Paulo, Brazil.
Ventricular assist devices have been widely accepted as an alternative treatment for advanced heart failure, while heart transplantation is a limited procedure because of the shortage of donors. In face of a scarce availability of these devices, many centers around the world have developed their own technologies. We describe historical and general features of the main ventricular assist devices developed at the Instituto Dante Pazzanese de Cardiologia.
View Article and Find Full Text PDFPhysiol Res
July 2025
Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Cardiac atrophy is the most common complication of prolonged application of the left ventricle (LV) assist device (LVAD) in patients with advanced heart failure (HF), obviously, it is a consequence of LVAD-induced mechanical unloading. Previous studies employing heterotopic heart transplantation (HTx) as a model of heart unloading after LVAD implantation discovered sex-linked differences in the course of unloading-induced in the healthy hearts. It remains to be clarified if sex-related differences are present in the failing hearts after heterotopic HTx.
View Article and Find Full Text PDFMedicine (Baltimore)
July 2025
Institute of Hepatology and Epidemiology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.
Rationale: The coexistence of intrauterine and extrauterine pregnancies is termed heterotopic pregnancy (HP). Most reported cases of HP occur after assisted reproductive technology, and HP in a natural pregnancy (NP) is very rare, often discovered intraoperatively. HP is a significant challenge for obstetricians, gynecologists, and sonographers.
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