Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study aimed to compare automated three-dimensional Intrapulmonary Vessel Volume (IPVV) differences between lung and mediastinal windows in healthy individuals using quantitative measurements obtained from chest Computed Tomography (CT) plain scans.
Methods: A total of 258 participants (aged 21-83 years) with negative chest CT scans from routine physical examinations conducted between January to November 2023 were retrospectively enrolled. For each healthy participant, an algorithm was used to automatically extract total lung IPVVs as well as IPVVs for vessels of specific diameter. Differences in IPVVs were then compared between those extracted using the lung window and those extracted using the mediastinal window.
Results: The IPVVs for the entire lung, intrapulmonary arteries, intrapulmonary veins, and small pulmonary vessels (categorized by different diameters) extracted from the lung window were significantly higher than those extracted from the mediastinal window (p<0.01). No significant sex-based differences in IPVV were observed for pulmonary arteries and veins with diameters between 0.8 and 1.6 mm, as well as pulmonary veins with diameters between 2.4 and 3.2 mm. However, in pulmonary arteries and veins with diameters between 1.6 and 2.4 mm, females had significantly higher IPVVs than males. In all other cases, IPVVs were larger in males than in females.
Conclusion: This method of automatic IPVV extraction and quantitative assessment has been proven to be feasible. Automated IPVV expression effectively identified morphological characteristics of intrapulmonary vessels. The study has concluded IPVVs extracted from the lung window to be generally larger than those extracted from the mediastinal window.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0115734056354924241115102310 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
(Golden Syrian Hamster) Experimental Model of SARS-CoV-2 Infection Reveals That Lung Injury Is Associated with Phenotypic Differences Between SARS-CoV-2 Variants.
Viruses
July 2025
Laboratory of Technological Development in Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Despite the current level of public immunity to SARS-CoV-2, the early inflammatory events associated with respiratory distress in COVID-19 patients are not fully elucidated. Syrian golden hamsters, facultative hibernators, recapitulate the phenotype of SARS-CoV-2-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced severe acute lung injury seen in patients. In this study, we describe the predominance of the innate immune response in hamsters inoculated with four different SARS-CoV-2 variants, underscoring phenotypic differences among them.
View Article and Find Full Text PDFSUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension.
Int J Mol Sci
July 2025
Laboratory for Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ Groningen, The Netherlands.
Pulmonary arterial hypertension (PAH) is a rare, progressive, and incurable disease characterized by an elevated pulmonary blood pressure, extensive remodeling of the pulmonary vasculature, increased pulmonary vascular resistance, and culminating in right ventricular failure. Mitochondrial dysfunction has a major role in the pathogenesis of PAH and secondary right ventricular failure, and its targeting may offer therapeutic benefit. In this study, we provide proof-of-concept for the use of the mitochondrially active drug SUL-150 to treat PAH.
View Article and Find Full Text PDFLeft pulmonary artery atresia and MAPCA aneurysm.
Int J Cardiovasc Imaging
September 2025
Department of Radiology, Royal Papworth Hospital, Cambridge, UK.
Unilateral atresia of the pulmonary artery (UAPA) is a rare condition often associated with congenital cardiac anomalies, such as tetralogy of Fallot or septal defects. UAPA is linked to an altered development of the sixth aortic arch segment, resulting in the proximal interruption of the pulmonary artery and it often occurs on the side of the chest opposite the aortic arch [1]. As a compensatory mechanism, major aortopulmonary collateral arteries (MAPCAs) arise from systemic arteries to supply distal intrapulmonary branches of the atretic pulmonary artery.
View Article and Find Full Text PDFAnatomy of Pulmonary Lymphatics and Lymphoid Tissues.
Semin Ultrasound CT MR
September 2025
Satsuma Lab, Hawkes Institute, University College London, London, UK; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
This review summarizes the 3 components of the pulmonary lymphatic system: lymphatic channels, bronchus-associated lymphoid tissue (BALT), and intrapulmonary lymph nodes. Lymphatic vessels are distributed within the bronchovascular bundles, in the interlobular septa and visceral pleura, and around small pulmonary arteries and veins within the secondary pulmonary lobules. Normally invisible on CT, they may appear with lymphatic dilation or disease spreading via lymphatic routes.
View Article and Find Full Text PDFZero-echo time magnetic resonance imaging for visualizing pulmonary neoplasms.
BMC Med Imaging
July 2025
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Objective: To assess the ability of a zero-echo time sequence combined with a highly flexible adaptive image receiving coil (AIRTM coil) to visualize pulmonary neoplasms.
Methods: A total of 42 patients with pulmonary neoplasms were included, all of whom underwent chest CT and MRI examinations. A highly flexible AIRTM coil was used.