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Osteoporosis compromises bone strength, making bone more susceptible to fractures. Decreased bone density heightens susceptibility to femoral neck fractures. The study investigated the impact of bone density on implant performance across three categories of bone quality: healthy, osteopenic, and osteoporotic. The effectiveness of three commonly used implant types (Femoral Neck System, Dynamic Condylar Screw, and Dynamic Hip Screw, where later two equipped with an anti-rotational screw) was evaluated through finite element analysis for treating Pauwels type III fracture. The bone geometry and material properties were based on a subject-specific CT data. The density and Young's modulus of bone elements were adjusted to simulate osteopenic and osteoporotic bone. FE models were developed and the peak loading values for normal walking and stair climbing conditions were considered. Stability and performance of the implant were assessed using bone strain, implant stress, deformation and rotation of the femoral head, micromotion at the interfaces, strain shielding, and risk of implant cut-out. Except for DCS with AR-screw and FNS implants under stair climbing conditions in weaker bone qualities, the implant stress remained within the yield limit of Ti-alloy. The comprehensive assessment identified DHS2 as the preferred implant option for treating such fractures, even in poor bone quality. The risk of cut-out risk was up to 3.9% higher in DCS2 and 6.3% higher in FNS implanted models than in DHS2. The effect of change in bone quality was comparatively less in DHS2 implants than the other two types.
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http://dx.doi.org/10.1177/09544119251333671 | DOI Listing |
Ultrasound Med Biol
September 2025
State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address:
Objective: Diabetic foot ulcer (DFU) is a common and serious complication of diabetes, often leading to infection, amputation and poor quality of life. Bone marrow mesenchymal stem cells (BMSCs) have shown promise in treating chronic wounds, but their therapeutic efficacy is limited due to poor survival and low regenerative activity. Low-intensity pulsed ultrasound (LIUS), a non-invasive physical modality, has been shown to enhance the biological behavior of BMSCs.
View Article and Find Full Text PDFJ Orthop Sci
September 2025
Department of Orthopaedic Surgery, NHO Saga Hospital, 1-20-1 Hinode, Saga 849-0923, Japan.
Background: Hounsfield units (HU) on computed tomography (CT) are strongly correlated with bone mineral density (BMD) and may aid in osteoporosis screening. However, there is no standardized method for assessing bone density in displaced femoral head fractures. This study aimed to measure HU values in the femoral head using preoperative post-fracture CT images of patients with intertrochanteric femoral fractures and investigate whether it correlated with BMD measured by dual-energy X-ray absorptiometry (DXA).
View Article and Find Full Text PDFOrthop Traumatol Surg Res
September 2025
Service de Chirurgie Orthopédique Pédiatrique, Hôpital Universitaire Robert-Debré, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, 48 Boulevard Sérurier, 75019 Paris, France.
Sickle cell disease is the most common serious genetic disease in the world. It is a systemic disease, characterized by vaso-occlusive phenomena, especially in the bone capillary network. Orthopedic complications are thus the most common, with a strong impact on quality of life.
View Article and Find Full Text PDFLife Sci Alliance
December 2025
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA
Nε-lysine acetylation in the lumen of the ER requires two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. They are type II membrane proteins and belong to the larger GNAT superfamily of acetyltransferases. Their enzymatic activity is tightly coupled to the import of acetyl-CoA in the lumen of the ER by AT-1/SLC33A1.
View Article and Find Full Text PDFBr J Haematol
September 2025
Platform of Molecular Analysis for Mastocytosis and MCAD (CEREMAST), Department of Biological Hematology, Pitié-Salpêtrière Hospital, AP-HP, Paris Sorbonne University, Paris, France.
Mastocytosis is categorized into cutaneous mastocytosis (CM), mast cell sarcoma and systemic mastocytosis (SM). Within SM, indolent SM (ISM) is the more frequent subtype. Adult patients with CM but without an extracutaneous biopsy are classified as having mastocytosis in the skin (MIS), a provisional diagnosis.
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