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Introduction: This study uses a non-linear model to explore the impact mechanism of change rates between internet search behavior and confirmed COVID-19 cases. The research background focuses on epidemic monitoring, leveraging internet search data as a real-time tool to capture public interest and predict epidemic development. The goal is to establish a widely applicable mathematical framework through the analysis of long-term disease data.
Methods: Data were sourced from the Baidu Index for COVID-19-related search behavior and confirmed COVID-19 case data from the National Health Commission of China. A logistic-based non-linear differential equation model was employed to analyze the mutual influence mechanism between confirmed case numbers and the rate of change in search behavior. Structural and operator relationships between variables were determined through segmented data fitting and regression analysis.
Results: The results indicated a significant non-linear correlation between search behavior and confirmed COVID-19 cases. The non-linear differential equation model constructed in this study successfully passed both structural and correlation tests, with dynamic data fitting showing a high degree of consistency. The study further quantified the mutual influence between search behavior and confirmed cases, revealing a strong feedback loop between the two: changes in search behavior significantly drove the growth of confirmed cases, while the increase in confirmed cases also stimulated the public's search behavior. This finding suggests that search behavior not only reflects the development trend of the epidemic but can also serve as an effective indicator for predicting the evolution of the pandemic.
Discussion: This study enriches the understanding of epidemic transmission mechanisms by quantifying the dynamic interaction between public search behavior and epidemic spread. Compared to simple prediction models, this study focuses more on stable common mechanisms and structural analysis, laying a foundation for future research on public health events.
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http://dx.doi.org/10.3389/fpubh.2025.1435513 | DOI Listing |
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
JAMA Neurol
September 2025
Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro,' "Pia Fondazione Cardinale G. Panico," Tricase, Lecce, Italy.
Importance: Comprehensive incidence and prevalence rates of frontotemporal dementia are currently not available.
Objective: To estimate the incidence and prevalence of frontotemporal dementia and its clinical variants in the overall population and age subgroups.
Data Sources And Study Selection: We systematically searched PubMed, EMBASE, and Scopus between January 1, 1990, and October 22, 2024, for population-based studies estimating the incidence and/or prevalence of FTD.
Elife
September 2025
Center for Mind and Brain, University of California, Davis, Davis, United States.
Visual search relies on the ability to use information about the target in working memory to guide attention and make target-match decisions. The 'attentional' or 'target' template is thought to be encoded within an inferior frontal junction (IFJ)-visual attentional network. While this template typically contains veridical target features, behavioral studies have shown that target-associated information, such as statistically co-occurring object pairs, can also guide attention.
View Article and Find Full Text PDFObjectives: Azapirone-class drugs are partial 5-HT1A receptor agonists commonly used to treat anxiety disorders. Prior experimental studies have so far demonstrated that these drugs have low potential for dependence and problematic use and are considered safe treatment options compared with benzodiazepines. However, recent evidence suggesting the contrary raises concerns about their safety.
View Article and Find Full Text PDFObjectives: Cocaine use disorder (CUD) affects 1.4 million people in the United States, yet no FDA-approved treatments exist. In 2023, the Food and Drug Administration (FDA) released a draft guideline on treatments for stimulant use disorders, providing direction for trial design, outcomes, and population selection.
View Article and Find Full Text PDF