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With the rapidly growing demand for wearable sensor devices across a range of applications, sensing technology has been rapidly advancing. However, challenges such as limited sensitivity, device instability, and trade-offs between performance and recyclability remain unaddressed. We report the facile fabrication of a recyclable dynamic disulfide hydrogel from an amphiphilic polyethylene-glycol-based thioctic acid derivative with hydrophilic/hydrophobic characteristics. The hydrogel demonstrates decent thermal stability and adequate mechanical properties, including elasticity, compressibility, and reprocessing capability. It is also integrated into a microstructured capacitive sensor, demonstrating a sensitivity of up to 1.14 kPa, rapid response times within 20 ms, and robust functioning stability up to 400 consecutive cycles. These properties make it particularly intriguing for the sustainable development of high-performance wearable sensors.
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http://dx.doi.org/10.1002/chem.202500407 | DOI Listing |
Med Int (Lond)
August 2025
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan 410060, P.R. China.
S-glutathionylation (SSG), a redox-sensitive post-translational modification mediated by glutathione, regulates protein structure and function through reversible disulfide bond formation at cysteine residues. Glutaredoxins (GRXs), pivotal antioxidant enzymes, catalyze SSG dynamics to maintain thiol homeostasis. Recent advances in redox proteomics have revealed that SSG dysregulation is intricately linked to neurodegenerative, cardiovascular, pulmonary and malignant diseases.
View Article and Find Full Text PDFACS Macro Lett
September 2025
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
Polyesters are a widely used class of biomaterials thanks to their (bio)degradability and tunable thermomechanical properties. Introducing dynamic disulfide bonds into their backbone enables them to be degraded through different routes and also imparts self-healing properties. However, while numerous polymerization protocols exist with which to introduce disulfide bonds into linear polymers, these methods lack the versatility needed to produce materials with diverse thermomechanical properties.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Institute of Pharmaceutical Science, King's College London, Franklin Wilkins Building, Stamford Street, London, SE1 9NH, UK.
As supramolecular assemblies, polypseudorotaxanes (PPR) exhibit inherent advantages in modular adaptability and structural programmability, with the potential to build tuneable platforms integrating various functionalities. Here we report the "one-pot" preparation of a self-assembled thiol-rich PPR (SPPR), where thiolated-α-cyclodextrins (SHαCD) spontaneously thread onto polymers, and are then crosslinked into a three-dimensional network by the thermally-triggered oxidation of thiols into disulfide bonds. The dynamic thiol groups along the SPPR provide remarkable modularity for the functionalization of thiophilic metal nanoparticles (NPs), exemplified by two application vectors.
View Article and Find Full Text PDFChem Asian J
September 2025
Department of Chemistry, Indian Institute of Technology Bhilai, Durg, Chhattisgarh, 491001, India.
Self-healing polymeric coatings represent a transformative class of smart materials capable of autonomously or stimuli-responsively repairing mechanical or environmental damage, thereby significantly extending the operational lifespan of protected substrates. This review systematically elucidates the underlying mechanisms and chemistries enabling self-healing behavior, encompassing both extrinsic strategies such as microcapsules, microvascular networks, and corrosion inhibitor reservoirs and intrinsic approaches based on dynamic covalent (e.g.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
College of Chemistry, Huazhong Agricultural University, Wuhan 430070, China.
High-nickel LiNiCoMnO (NCM83) cathodes suffer from interfacial instability resulting from cathode-electrolyte reactions and anisotropic mechanical strain within secondary particles. Herein, we present a mechanically adaptive cathode-electrolyte interphase (CEI) engineered via a dynamic covalent network that features a supramolecular ion-conducting polyurethane ureido-pyrimidinone (SPU-UPy) elastomer. The dynamic network integrates cooperative hydrogen bonds and disulfide bonds and imparts exceptional mechanical resilience and autonomous self-healing capabilities that allow it to accommodate volume fluctuations without compromising structural integrity.
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