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It seems logical to divide the macrocirculation into systemic and pulmonary circulation, but it is rare in clinical practice to further subdivide microcirculation into systemic and pulmonary microcirculation. Both systemic and pulmonary microcirculations play important roles in the development and progression of critical illness. Therefore, targeting the overall microcirculation status for clinical treatment may overlook the heterogeneity of different critically ill patients. It seems unavoidable to further subdivide the microcirculation, so this review explains the differences in structure, function, blood flow regulation, and other important aspects between systemic and pulmonary microcirculation, systematically presenting the concept of "double microcirculation." At the same time, to refine the critical care treatment and even improve the prognosis of critically ill patients, we further propose and explain the treatment key points based on "double microcirculation protection."
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http://dx.doi.org/10.1177/08850666251321786 | DOI Listing |
Heart Lung Circ
September 2025
Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, WA, Australia; Medical School, The University of Western Australia, Perth, WA, Australia; Curtin Medical School, Curtin University, Bentley, WA, Australia. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, with a reach extending beyond the liver to include other metabolic syndrome-related disorders. Cardiovascular disease and type 2 diabetes mellitus are recognised non-communicable disorders and often downstream complications of MASLD and share similar risk factors. However, MASLD has not been afforded parity alongside other cardiometabolic non-communicable disorders, including the cardiovascular-kidney-metabolic (CKM) syndrome.
View Article and Find Full Text PDFPhysiol Rep
September 2025
Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
We evaluated the systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from whole-body, passive heating in young and older adults. Supine mean arterial pressure (MAP), cardiac output (Q; acetylene washin), systemic vascular conductance (SVC), heart rate (HR), and stroke volume (SV) were evaluated in 16 young (8F, 18-29 years) and nine older (6F, 61-73 years) adults at normothermic baseline and for 60-min passive heating and 120-min normothermic recovery. Externally applied neck pressure was used to evaluate HR, brachial vascular conductance, and MAP responses to carotid baroreceptor unloading.
View Article and Find Full Text PDFJ Thromb Haemost
September 2025
Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, MN, USA.
Background: Balancing the risks of thrombotic and bleeding events in people with advanced kidney disease is a clinical challenge.
Objectives: To estimate rates of major adverse thrombotic events (MATEs) and bleeding events in individuals with chronic kidney disease (CKD) stages 4 or 5 or with end-stage kidney disease (ESKD) receiving hemodialysis (HD) or peritoneal dialysis (PD).
Methods: Using administrative claims from a 20% Medicare sample, Optum's de-identified Clinformatics Data Mart Database, and the US Renal Data System from 2016-2019, we identified individuals with CKD stages 4 or 5 and individuals with dialysis-dependent ESKD.
Int J Biol Macromol
September 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China. Electronic address:
Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications. This study systematically investigated the oral absorption characteristics and tissue distribution of ME-2, a homogeneous polysaccharide from Auricularia auricula-judae, using a dual-labeling pharmacokinetic approach. First, a fluorescein-5-thiosemicarbazide (FTSC)-based quantitative method was established to analyze plasma pharmacokinetics and tissue concentrations of ME-2, demonstrating robust methodological stability (intra-/inter-day RSD < 15 %) and accuracy (recovery rate 95-103 %).
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Cell and Molecular Biology, University of Hawaii, Honolulu, HI, USA.
Diagnoses of prediabetes and metabolic syndromes, such as metabolic-associated steatotic liver disease (MASLD), are increasing at an alarming rate worldwide, often simultaneously. A significant consequence of these is high risk of cardiovascular disease, highlighting the need for cardiac-specific therapeutics for intervention during the prediabetic stage. Recent studies have demonstrated that chemogenetic activation of the cardiac parasympathetic system through hypothalamic oxytocin (OXT) neurons provides cardioprotective effects in heart disease models by targeting excitatory neurotransmission to brainstem cardiac vagal neurons.
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