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BACKGROUND Pediatric anesthesia emergence delirium (PAED), with symptoms including agitation, hyperactivity, and confusion, is common in children undergoing general anesthesia. This study aimed to compare the effect of an endotracheal tube (ETT) and a laryngeal mask airway (LMA) on emergence delirium (ED) in 73 children undergoing strabismus surgery. MATERIAL AND METHODS Seventy-three children aged 3 to 9 years were enrolled and randomly assigned to 2 groups: 36 patients in the LMA group (group L) and 37 patients in the ETT group (group E). The primary endpoint was the existence of ED, defined as a PAED scale score exceeding 10. Secondary endpoints were PAED scale scores, the Face, Legs, Activity, Cry, Consolability (FLACC) scale scores, measured every 5 min, intubation and extubation times, complications, airway responses following intubation, and post-anesthesia care unit (PACU) stay duration. RESULTS Seventy-three patients were included in the final analysis. Intubation time and PACU stay were significantly shorter in group L than in group E (P=0.02). Group E demonstrated higher PAED scale scores at 0, 5, 10, 20, and 25 min after surgery (P=0.062, 0.029, 0.019, 0.007, and 0.028, respectively). FLACC scores were also higher in group E, at 20, 25, and 30 min after surgery (P=0.016, 0.029, and 0.026, respectively). The presence of ED was lower in group L than in group E, at 5, 10, and 15 min (P=0.024, 0.008, and 0.025, respectively). CONCLUSIONS LMA is better than ETT in pediatric strabismus surgery, as it reduces postoperative pain and PACU stay.
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http://dx.doi.org/10.12659/MSM.948351 | DOI Listing |
JCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
Mol Pharm
September 2025
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-Ku, Kyoto 606-8501, Japan.
Fibroblast activation protein (FAP) is an attractive biomarker for tumor-targeting radioligands. While [Ga]Ga-FAPI-46 is a promising FAP-targeting radioligand for cancer diagnosis, clinical application of [Lu]Lu-FAPI-46 for targeted radionuclide therapy is limited due to its insufficient tumor retention. Albumin binder (ALB) including 4-(-iodophenyl)butyric acid is widely utilized to improve tumor accumulation of radioligands.
View Article and Find Full Text PDFClin J Am Soc Nephrol
September 2025
Kidney Division, Peking University First Hospital, Peking University Institute of Nephrology; Key Laboratory of Kidney Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, China.
Background: The Therapeutic Effects of Steroids in IgA Nephropathy Global (TESTING) trial demonstrated that glucocorticoid therapy reduced proteinuria and improved kidney outcomes in patients with Immunoglobulin A Nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a central role in IgAN pathogenesis by promoting immune complex formation. However, the effects of glucocorticoid on pathogenic IgA levels remain unclear.
View Article and Find Full Text PDFJ Clin Invest
September 2025
Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.