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Introduction: Simultaneous bilateral total knee arthroplasties (SBTKA) are common in Asia, but surgeons may have a body mass index (BMI) threshold for performing these procedures. However, no guidelines regarding patient weight and SBTKA exist in the literature. We hypothesized that SBTKA can be performed safely and efficiently for morbidly obese patients. We aimed to compare 1) the rate of complications within one year after surgery, 2) operative time, blood loss, and length of stay, and 3) clinical outcomes at one year after SBTKA in patients with BMI < 30 versus 30 < BMI < 40 and BMI > 40.
Methods: In this retrospective comparative matched (age, ASA score) study, we evaluated 113 patients who underwent SBTKA (posterior stabilized cemented TKA), between 2019 and 2022. The patient population was grouped based on their BMI: BMI < 30 (33 patients), 30 < BMI < 40 (43 patients), and BMI > 40 (37 patients). A complication was defined as an event that could be classified as a grade > 3 according to the Clavien-Dindo classification within one year of surgery. Data on complication rate, operation time, blood loss, and preoperative and post-operative function KSS at one year were compared.
Results: No significant difference in the occurrence of early complications between the three groups was observed. One patient was readmitted for periprosthetic fracture in the BMI < 30 group. There was no significant difference in operative time, blood loss, and KSS score at one year between the three groups. A significant functional improvement was observed in all three groups at the one-year follow-up.
Discussion: This study suggests that SBTKA in patients with a BMI > 40 is safe, with no increased complications, similar surgical time, and blood loss. Significant functional improvement was observed at one year postoperatively. While promising, further multi-center studies are needed to confirm these findings and evaluate long-term outcomes.
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http://dx.doi.org/10.1051/sicotj/2025019 | DOI Listing |
BMC Oral Health
September 2025
Department of Oral Medicine and Periodontology, Ain Shams University, Cairo, Egypt.
Background: Periodontitis, a chronic inflammatory disease of tooth-supporting tissues, shows significant associations with systemic conditions like type 2 diabetes mellitus (T2DM) and obesity. These metabolic disorders share chronic inflammatory pathways that may influence periodontal disease severity. This study investigated these relationships using advanced quantifiable metrics - periodontal epithelial surface area (PESA) and periodontal inflammatory surface area (PISA).
View Article and Find Full Text PDFJ Mol Histol
September 2025
Department of Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry, 605014, India.
Survivin, an inhibitor of apoptosis protein, is minimally expressed in normal adult tissues but overexpressed in multiple cancers. This study investigates survivin expression alongside autophagy markers ATG7 and LC3B in seven solid tumor types in Indian patient samples. Immunohistochemical analysis was performed on 48 cancer tissue samples (breast n = 7, buccal n = 6, cervical n = 5, colon n = 8, renal n = 6, liver n = 10, thyroid n = 6) and adjacent normal tissues (n = 9) using anti-human antibodies against survivin, ATG7, and LC3B.
View Article and Find Full Text PDFObes Surg
September 2025
Stanford University, Stanford, United States.
Background: Bariatric surgery pre-operative workup mandates many multidisciplinary visits demanding patient's commitment in time and travel. Due to the COVID pandemic, our bariatric clinic transitioned to a telemedicine model. The objective of this work is to determine the impact of this shift.
View Article and Find Full Text PDFObes Surg
September 2025
Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1305 York Avenue, 4th Floor, New York, NY, 10021, United States.
Introduction And Aim: Despite ESG's efficacy in promoting weight loss, data on its impact on body composition is limited. This study evaluated ESG's effectiveness in improving body composition and metabolic parameters over 6 and 12 months using InBody analysis.
Methods: We prospectively analyzed patients with obesity (BMI > 30 kg/m or > 27 with comorbidities) who underwent ESG between August 2021 and May 2024.
Background: Metabolic bariatric surgery (MBS) is the most effective obesity treatment. The increasing number of MBS among young patients has led to more post-bariatric pregnancies. Our study investigates how breastfeeding duration impacts postpartum weight retention and health outcomes for mothers and babies after MBS.
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