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Background: Coronavirus disease 2019 (COVID-19), a global pandemic, has greatly altered our daily lifestyle. Although there have been many reports on the association between COVID-19 and sleep disorders, none have examined this association with continuous positive airway pressure (CPAP) therapy control. Therefore, we aimed to elucidate the impact of lifestyle changes on CPAP users during the COVID-19 pandemic in Japan.
Methods: This study included patients with obstructive sleep apnea (OSA) who were treated with CPAP. We used an original lifestyle questionnaire to collect data on their exercise, amount of food, alcohol consumption, sleep time, and subjective stress. We classified the patients into the following four groups: (I) work from home (WFH); (II) WFH and commuting (hybrid working); (III) commuting; and (IV) unemployed. Downloaded data were used to analyze CPAP adherence. When we compared the physical activity and sleep duration, working respondents were categorized into two groups, namely: (I) the home group, which comprised WFH and hybrid working; and (II) the commuting group without telecommuting at home.
Results: Overall, 663 patients enrolled in this study, and among them, 506 (76.3%) were workers. Additionally, 364 (71.9%) participants changed their work style from commuting due to the COVID-19 pandemic. Physical activity decreased significantly in 60.9% of the participants in the home group (P<0.01). The sleep duration increased significantly in 19% of the participants (P<0.05). No significant difference was found in Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) score among the groups classified based on work styles. CPAP use significantly shorter in working respondents who were hybrid or commuting workers (P<0.01).
Conclusions: The COVID-19 pandemic has resulted in many lifestyle changes. More than 50% of workers who was CPAP user changed their work style, resulting in decreased physical activity, and commuters tended to have shorter durations and lower rates of CPAP use compared to teleworkers.
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http://dx.doi.org/10.21037/jtd-24-1194 | DOI Listing |
Macromol Biosci
September 2025
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey.
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has highlighted the critical need for safe and effective vaccines. In this study, subunit nanovaccine formulations were developed using the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein encapsulated in polymeric nanoparticles composed of poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL). Two surfactants, poly(vinyl alcohol) (PVA) and sodium cholate (SC), were evaluated during formulation via a modified water-in-oil-in-water (w/o/w) emulsion-solvent evaporation method.
View Article and Find Full Text PDFJAMA
September 2025
Moderna, Inc, Cambridge, Massachusetts.
Clin Transl Sci
September 2025
Food and Drug Administration, Silver Spring, Maryland, USA.
Since the first decentralized clinical trial (DCT) was conducted in 2011, there has been an increased usage of DCT due to its benefits of patient-centricity and generalizability of findings. This trend was further expedited by the global COVID-19 pandemic. We identified 23 case studies across various therapeutic areas and grouped them into different categories according to their purposes-by necessity, for operational benefits, to address unique research questions, to validate innovative digital endpoints, or to validate decentralization as a clinical research platform.
View Article and Find Full Text PDFJAMA
September 2025
Department of Pulmonary and Critical Care Medicine, Xiangtan Central Hospital, Xiangtan, China.
Child Psychiatry Hum Dev
September 2025
School of Psychology, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.
The COVID-19 pandemic presented a unique opportunity to investigate the longitudinal associations between parents' pre-pandemic mental health issues and their emotion-related parenting practices during the pandemic, as well as the impact on children's socio-emotional functioning. The present study aimed to: 1) investigate associations between pre-existing parent mental health issues (2019) with children's long-term socio-emotional functioning (2021), via changes in emotion-related parenting practices during the COVID-19 pandemic (2020); and 2) test whether COVID-19 pandemic-related environmental stressors during 2020 and 2021 exacerbated associations between emotion-related parenting practices and children's socio-emotional functioning. Data were drawn from the Child and Parent Emotion Study (CAPES).
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