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Habitat loss and degradation associated with industrial development is the primary threat and dominant driver of biodiversity loss globally. Spatially-explicit datasets that estimate human pressures are essential to understand the extent and rate of anthropogenic impacts on ecosystems and are critical to inform conservation commitments and efforts under the Global Biodiversity Framework. We leveraged the human modification framework to generate comprehensive, consistent, detailed, robust, temporal, and contemporary datasets to map cumulative and individual threats associated with industrial human activities to terrestrial biodiversity and ecosystems from 1990 to 2022. In ~2022, 43% of terrestrial lands had very low levels of modification, while 27%, 20%, and 10% had low, moderate, and high modification, respectively. Nearly 2/3 of biomes and 1/2 of ecoregions currently are moderately-modified, and 24% of terrestrial ecosystems (31 M km) experienced increased modification from 1990 to 2020. About 29% of countries and 31% of ecoregions might also be particularly vulnerable to biodiversity loss given their above-average increased modification and less than 30% protection.
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http://dx.doi.org/10.1038/s41597-025-04892-2 | DOI Listing |
J Med Case Rep
September 2025
Department of Anesthesiology, LMU University Hospital Munich LMU, Marchioninistrasse 15, 81377, Munich, Germany.
Background: The treatment of critically ill patients in intensive care units is becoming increasingly complex. For example, organ transplants are regularly carried out, the recipients are seriously ill, and the postoperative course can be complicated. This is why organ replacement and hemadsorption procedures are becoming increasingly important.
View Article and Find Full Text PDFLipids Health Dis
September 2025
Epidemiology, Medical Faculty, University of Augsburg, Stenglingstr. 2, Augsburg, 86156, Germany.
Background: This study aimed to investigate the gender-specific associations of skeletal muscle mass and fat mass with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver fibrosis in two population-based studies.
Methods: Analyses were based on data from the MEGA (n = 238) and the MEIA study (n = 594) conducted between 2018 and 2023 in Augsburg, Germany. Bioelectrical impedance analysis was used to evaluate relative skeletal muscle mass (rSM) and SM index (SMI) as well as relative fat mass (rFM) and FM index (FMI); furthermore, the fat-to-muscle ratio was built.
Nat Struct Mol Biol
September 2025
Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford, UK.
X-chromosome inactivation (XCI) in mammals is orchestrated by the noncoding RNA X-inactive-specific transcript (Xist) that, together with specific interacting proteins, functions in cis to silence an entire X chromosome. Defined sites on Xist RNA carry the N-methyladenosine (mA) modification and perturbation of the mA writer complex has been found to abrogate Xist-mediated gene silencing. However, the relative contribution of mA and its mechanism of action remain unclear.
View Article and Find Full Text PDFEur J Neurosci
September 2025
The Tampa Human Neurophysiology Lab, Department of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Sensory areas exhibit modular selectivity to stimuli, but they can also respond to features outside of their basic modality. Several studies have shown cross-modal plastic modifications between visual and auditory cortices; however, the exact mechanisms of these modifications are yet not completely known. To this aim, we investigated the effect of 12 min of visual versus sound adaptation (referring to forceful application of an optimal/nonoptimal stimulus to a neuron[s] under observation) on the infragranular and supragranular primary visual neurons (V1) of the cat (Felis catus).
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
November 2025
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Background And Objectives: Myelitis is a relatively common clinical entity for neurologists, with diverse underlying causes. The aim of this study was to describe the incidence of myelitis, its causes, clinical presentation, and factors predicting functional outcomes and relapses.
Methods: Using the Swedish National Patient Registry, we identified all adult patients in Stockholm County between 2008 and 2018 using International Classification of Diseases, 10th Edition (ICD-10) codes likely to include myelitis.