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In India, burns represent a serious public health concern due to high death and disability rates. A national burn registry was proposed under the National Program on Prevention and Management of Burn Injuries. This study reports experiences from the first pilot burn registry in India, presenting patient profiles and implementation perspectives. Five burn centers were selected to implement a prospective, multicentric burn registry in northern India. Every burn patient at the study sites who met the inclusion criteria was recruited. Patients' sociodemographic and burn injury profiles, determinants of mortality, and predictors of poor recovery outcome (death or discharge with disability) are presented based on descriptive, bivariate, and binary logistic regression analyses. From August 2020 to March 2022, a total of 908 patients were enrolled, with 61% being male and 39% female. Approximately 43% of acute burn patients were referred from other health facilities. The most frequent causes of burns were flame (37%), hot liquid (28%), and electric (28%). Accidental burns accounted for 88% of cases, with 73% occurring at patients' homes, and 48% being classified as major burns (≥20% Total Body Surface Area [TBSA]). Mortality was significantly higher among female patients with TBSA higher than 40% and non-accidental burns. The odds of poor recovery were higher for TBSA >40%, electric burns, and non-accidental burns. The implementation experience highlights the need to broaden the scope of the burn registry to include more comprehensive data, which can enhance the planning and delivery of burn care services.
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http://dx.doi.org/10.1093/jbcr/iraf042 | DOI Listing |
J Allergy Clin Immunol
September 2025
University College London, Institute of Immunity and Transplantation, London, UK; Department of Immunology, Royal Free London NHS Foundation Trust, London, UK.
Background: A scoping review was conducted for the European Society for Immunodeficiencies (ESID) Clinical Working Party (CWP) to evaluate clinical management guidelines for Inborn Errors of Immunity (IEIs). The goal was to identify gaps to inform future guideline development, thereby supporting improved clinical practice and patient outcomes.
Methods: A search strategy was developed in collaboration with the ESID CWP and an information specialist.
Trials
September 2025
Institute for Global Health, University College London, London, UK.
Background: Antiretroviral therapy (ART) has transformed HIV into a manageable health condition with normal life expectancy. However, people with HIV continue to have poorer mental health compared to background populations, which may be linked to stigma, lack of social support, or socioeconomic challenges. Personalised care aims to improve the outcomes of people with long-term health conditions and the National Health Service (NHS) Long Term Plan looks to implement this (including access to health coaching and social prescribing).
View Article and Find Full Text PDFSage Open Pediatr
August 2025
KCMC University, Moshi, United Republic of Tanzania.
Objective: This study aimed to estimates Disability-adjusted life years (DALYs) for pediatric injury patients at a zonal referral hospital.
Methods: This is a retrospective cohort study using pediatric injury registry data, DALYs for pediatric injured patients was calculated by adding the Years of life lost (YLL) and Years lived with disability (YLD). Discounting rate of 3%, age weighting parameter of 0.
Mil Med Res
August 2025
Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing, 400042, China.
Background: Lumbar disc degeneration (LDD) displays considerable heterogeneity in terms of clinical features and pathological changes. However, researchers have not clearly determined whether the transcriptome variations in LDD could be used to identify or interpret the causes of heterogeneity in clinical features. This study aimed to identify the transcriptomic classification of degenerated discs in LDD patients and whether the molecular subtypes of LDD could be accurately predicted using clinical features.
View Article and Find Full Text PDFJ Am Coll Cardiol
August 2025
Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department