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Hyperspectral imaging is a promising tool for identifying ischemic necrotic small intestine. To analyze the causes of small bowel necrosis, studying characteristic bands is crucial. However, differences in samples and spectral acquisition devices limit the availability of all bands for analysis, posing challenges in selecting bands adapted to individual variations. This study proposed a method based on the least trimmed squares algorithm, enhanced with regularization, to identify characteristic bands. The method successfully differentiated normal and necrotic tissue and analyzed necrosis causes, which originated from the same rabbit, different rabbits, and different necrosis durations. It identified 763 nm as the characteristic band, corresponding to the deoxyhemoglobin absorption peak. This approach offers accurate, automated band identification while addressing sample and device discrepancies, enabling the selection of more suitable characteristic bands.
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http://dx.doi.org/10.1002/jbio.70023 | DOI Listing |
J Biochem Mol Toxicol
September 2025
Department of Molecular Biology and Genetics, Faculty of Science, Bartin University, Bartin, Turkey.
Schiff bases containing sulfonyl units are important compounds because of their potential biological properties in the therapeutical field. In this study, three novel ligands (L1, L2, and L3) containing the sulfonyl groups, a derivative of Schiff base, were synthesized, and their molecular structures were characterized by FT-IR, H-NMR, C NMR, and elemental analysis results. The antiproliferative activities of these Schiff base ligands were evaluated against human colon cancer (HT-29 and Caco-2) and mouse fibroblast (L929) cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.
View Article and Find Full Text PDFLinear focal elastosis (LFE), also known as elastotic striae, is a rare cutaneous condition characterized by abnormal or increased deposition of elastic fibers in the dermis. It typically presents as asymptomatic, atrophic, or hyperpigmented linear bands, most commonly on the back. We report a case of LFE in a 15-year-old healthy male who presented with multiple asymptomatic, parallel hypopigmented linear bands with hyperpigmented borders on his back.
View Article and Find Full Text PDFNeurol Clin Pract
October 2025
Department of Neurology, University of Colorado School of Medicine, Aurora.
Background And Objectives: The presence of oligoclonal bands (OCBs) indicates an augmented immune response within the CNS and is integral to the diagnosis of multiple sclerosis (MS). Expert consensus panels recommend OCB testing for conditions other than MS, despite limited data to suggest diagnostic value. Our objectives were to evaluate the spectrum of disease etiologies associated with OCBs and determine the accuracy of OCBs in identifying autoimmune disorders affecting the CNS.
View Article and Find Full Text PDFBiomed Eng Lett
September 2025
Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, South Korea.
Unlabelled: Purpose: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a sleep disorder considered to be a prodromal stage of neurodegeneration disease and is often accompanied by cognitive impairments. The purpose of this study was to investigate spatiotemporal characteristics of abnormal oscillatory cortical activity associated with dysfunction of visuospatial attention in iRBD based on an explainable machine learning approach. Methods: EEGs were recorded from 49 iRBD patients and 49 normal controls while they were performing Posner's cueing task and transformed to cortical current density time-series.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
Department of Civil and Environmental Engineering, Hanyang University, Ansan, 15588, Republic of Korea. Electronic address:
Background: Standard Unified BioAccessibility Research Group of Europe (BARGE) Method (UBM) protocols for metal bioaccessibility assessment face challenges due to post-acidification precipitation, causing significant methodological inconsistencies across studies. This research systematically examined precipitate formation by characterizing protein-metal interactions and identifying specific proteins involved, leading to development of an enhanced UBM method for more reliable metal bioaccessibility measurements in consumer products. We focused on precipitation caused by acid injection during sample storage for subsequent instrumental analysis.
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