Fighting frailty, (osteo)sarcopenia, and fatigue: importance of unified definitions, accurate target identification, and high-quality clinical trials.

Curr Opin Clin Nutr Metab Care

Center for Translational Research in Aging and Longevity, Departments of Kinesiology & Sport Management, and Primary Care & Rural Medicine, Texas A&M University, College Station, Texas, USA.

Published: May 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCO.0000000000001121DOI Listing

Publication Analysis

Top Keywords

fighting frailty
4
frailty osteosarcopenia
4
osteosarcopenia fatigue
4
fatigue unified
4
unified definitions
4
definitions accurate
4
accurate target
4
target identification
4
identification high-quality
4
high-quality clinical
4

Similar Publications

Heart Failure (HF) is frequently associated with various non cardiovascular (CV) comorbidities significantly impacting HF prognosis. Indeed, the simultaneous presence of multiple diseases leads to an increased vulnerability, with frailty occurrence. This status implies poor quality of life and increased adverse events rate in terms of hospitalization and mortality.

View Article and Find Full Text PDF

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT.

Adv Sci (Weinh)

June 2025

Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

The brain plays a central role in aging and longevity in diverse model organisms. Morphological and functional alteration in the aging brain elicits age-associated neuronal dysfunctions. However, the primary mechanism deteriorating the brain functions to regulate the aging process remains incompletely understood.

View Article and Find Full Text PDF

Fighting frailty, (osteo)sarcopenia, and fatigue: importance of unified definitions, accurate target identification, and high-quality clinical trials.

Curr Opin Clin Nutr Metab Care

May 2025

Center for Translational Research in Aging and Longevity, Departments of Kinesiology & Sport Management, and Primary Care & Rural Medicine, Texas A&M University, College Station, Texas, USA.

View Article and Find Full Text PDF

Treating Presbyphonia in 2024: A Scoping Review.

J Voice

December 2024

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, AP-HM, Marseille, La Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, CEDEX 5, 13385 Marseille, France.

Presbyphonia is a multi-dimensional pathology. Therefore, its treatment should address its different affecting factors, including a global health management to fight geriatric frailty, improve overall physical strength, and limit medication side-effects. The specific therapies should address glottal gap closure and vocal folds' pliability.

View Article and Find Full Text PDF

Fostering healthy cognitive ageing in people living with HIV.

Lancet HIV

January 2025

MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces.

View Article and Find Full Text PDF