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We introduce a novel computational methodology for indexing the Euler characteristics of [Formula: see text]-dimensional objects by overlaying ([Formula: see text]+1)-dimensional chiral vector fields. Analogous to how the skyrmion number characterizes a two-dimensional magnetic skyrmion through the integration of the solid angle of its spin field, we generalize this principle to arbitrary dimensions. By iteratively applying a simple numerical process, we generate ([Formula: see text]+1)-dimensional chiral vector fields on [Formula: see text]-dimensional objects. The Euler characteristics of these objects are calculated by aggregating the local solid angles subtended by neighboring chiral vectors. In this study, we focus on verifying our method in two and three dimensions. For dimensions higher than three, we conduct preliminary experiments on simple objects to explore potential applicability. Although our method shows promising potential in higher dimensions, further investigation is required to fully understand its applicability beyond three dimensions.
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http://dx.doi.org/10.1038/s41598-025-95495-9 | DOI Listing |
Comput Biol Med
September 2025
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiation Oncology, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, De Boelelaan 1118, 1081 HV, Amsterdam, the Netherlands; Varian Medical Systems, a Siemens Heal
Background: Convolutional neural networks (CNNs) have emerged to reduce clinical resources and standardize auto-contouring of organs-at-risk (OARs). Although CNNs perform adequately for most patients, understanding when the CNN might fail is critical for effective and safe clinical deployment. However, the limitations of CNNs are poorly understood because of their black-box nature.
View Article and Find Full Text PDFJ Acoust Soc Am
August 2025
Mechanical Engineering, Indian Institute of Science, Bengaluru, Karnataka 560012, India.
This study investigates the sound transmission characteristics of an unbaffled simply supported plate excited by a plane wave incident at an arbitrary angle. The pressure jump across the unbaffled plate results from the combined effects of pure diffraction and pure radiation. In pure diffraction, the plane wave interacts with a rigid unbaffled plate, while in pure radiation, the pressure jump arises from the flexural vibrations of the plate.
View Article and Find Full Text PDFActa Trop
August 2025
School of Medical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
Dengue fever remains a significant public health challenge in Malaysia, with high case numbers reported annually. Effective control and mitigation strategies require robust analytical tools to understand transmission dynamics and guide interventions. This study utilized topological data analysis (TDA) to extract structural features from epidemiological dengue time series using Euler characteristic curve.
View Article and Find Full Text PDFbioRxiv
July 2025
Kentucky IDeA Network of Biomedical Research Excellence Data Science Core, University of Louisville, Louisville, Kentucky 40202, United States of America.
Background: As the availability of single-cell RNA sequencing (scRNA-seq) data expands, there is a growing need for robust methods that enable integration and comparison across diverse biological conditions and experimental protocols. Persistent homology (PH), a technique from topological data analysis (TDA), provides a deformation-invariant framework for capturing structural patterns in high-dimensional data.
Methods: In this study, PH was applied to a diverse collection of scRNA-seq datasets spanning eight tissue types to investigate how data integration affects the topological features and biological interpretability of the resulting representations.
As the core component of aviation optoelectronic equipment, vibration isolator plays a crucial role in attenuating high frequency mechanical vibrations from airborne platforms, thereby ensuring the clarity and stability of the optoelectronic imaging system. This paper presents what we believe to be a novel six degrees of freedom vibration isolator (SDFVI) and introduces its forward design methodology tailored to meet the high frequency attenuation requirements all six degrees of freedom in aviation optoelectronic system. Initially, a SDFVI is proposed based on the Stewart platform principle, which exhibits elastic characteristics in both translational and rotational directions.
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