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Article Abstract
Atypical face processing is a neurocognitive basis of social deficits in autism spectrum disorder (ASD) and a candidate cognitive marker for the disease. Although hundreds of risk genes have been identified in ASD, it remains unclear whether mutations in a specific gene may cause ASD-like atypical face processing. Dogs have acquired exquisite face processing abilities during domestication and may serve as an effective animal model for studying genetic associations of ASD-like atypical face processing. Here, we showed that dogs with mutations exhibited behavioral and attentional avoidance of faces, contrasting with wild-type controls. Moreover, neural responses specific to faces (versus objects) recorded from the electrodes over the temporal cortex were significantly decreased and delayed in mutants compared to wild-type controls. Cortical responses in the frontal/parietal region underlying categorization of faces by species/breeds were reduced in mutants. Our findings of atypical face processing in dogs with mutations provide a useful animal model for studying ASD mechanisms and treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963970 | PMC |
| http://dx.doi.org/10.1126/sciadv.adu3793 | DOI Listing |
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