Flecainide and atrial fibrillation cardioversion: what solutions at present and in the near future?

Europace

Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena 41125, Italy.

Published: March 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992564PMC
http://dx.doi.org/10.1093/europace/euaf063DOI Listing

Publication Analysis

Top Keywords

flecainide atrial
4
atrial fibrillation
4
fibrillation cardioversion
4
cardioversion solutions
4
solutions future?
4
flecainide
1
fibrillation
1
cardioversion
1
solutions
1
future?
1

Similar Publications

Fetal tachyarrhythmias, particularly supraventricular tachycardia (SVT) and atrial flutter (AFL), pose significant clinical challenges, especially when complicated by hydrops fetalis. This article provides a comprehensive review of the tachyarrhythmia types, the diagnostic modalities applied, and the therapeutic strategies followed in fetal tachyarrhythmias. Diagnostic techniques such as M-mode echocardiography and fetal magnetocardiography (fMCG) are highlighted for their capacity to provide real-time, high-quality assessments of fetal cardiac rhythms.

View Article and Find Full Text PDF

Catheter ablation plays a pivotal role in the management of atrial fibrillation (AF). Recent randomized controlled studies have shown that catheter ablation is superior to conventional antiarrhythmic medical treatment as first-line therapy in reducing symptoms, AF recurrences, and preventing progression of AF. If the examined antiarrhythmic medical regimens were given in therapeutic and adequate doses remains an open question.

View Article and Find Full Text PDF

Background: Flecainide is a Class IC antiarrhythmic drug used to treat arrhythmias such as atrial fibrillation (AF), paroxysmal supraventricular tachycardia, and ventricular tachycardia (VT). Its mechanism involves blocking sodium channels, leading to QRS widening, especially at higher heart rates. This property increases the risk of pro-arrhythmic events, particularly in patients with structural heart disease or ischaemia.

View Article and Find Full Text PDF

Background: Elevated intracardiac filling pressures create a proarrhythmic environment that facilitates the development or progression of atrial fibrillation (AF). Accelerated lower rate pacing results in atrial decongestion by lowering intracardiac filling pressure and therefore may have an antiarrhythmic effect.

Case Summary: A 70-year-old woman with paroxysmal AF on flecainide progressed to symptomatic rate-controlled persistent AF 5 months ago.

View Article and Find Full Text PDF

Background: Vernakalant is authorized in several countries, except in the U.S., where the FDA denied its commercialization due to safety concerns, generating debate about its use.

View Article and Find Full Text PDF