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Youth living with HIV (YLHIV) face multidimensional challenges, including stigma, mental health struggles, and socioeconomic instability, which are further magnified among adolescents and young adults with perinatally acquired HIV (APHIV). Peer-led differentiated service delivery (DSD) models providing tailored support for this population have demonstrated improved outcomes, though their adaptation and implementation in India remain underexplored. We examined multi-stakeholder perceptions within a peer-support DSD intervention in India, the I'mPossible Fellowship, designed to address the health, educational, and livelihood needs of APHIV. Between May and December 2023, we enrolled three stakeholder groups involved in the I'mPossible fellowship intervention: (1) intervention deliverers (APHIV "fellows"), (2) facilitators ("supervisors" of APHIV), and (3) beneficiaries (APHIV "peers"). To examine fellows' roles and growth, we conducted in-depth interviews with fellows (n=8; 75% female; mean age: 22.5 years) and supervisors (n=7). Aiming to explore fellow-peer interactions and perceived program impact, we conducted three focus group discussions with purposefully sampled peers (n=18; 66.7% male; mean age: 16.7 years). Data collected were audio recorded, transcribed, and translated from Kannada to English for coding and analysis. Thematic deductive analysis was combined with data triangulation across participant groups to synthesize findings. Five key themes emerged, highlighting the layered influences of the I'mPossible Fellowship. First, mentorship was an important theme that provided informational and emotional support for peers; second, peer influence arising from peer-to-peer interactions contributed to a sense of trust and affirmation. Third, personal growth experienced by fellows stimulated their motivation to fulfil their mentorship roles effectively. Fourth, complex systemic challenges, such as stigma and discrimination, hindered educational and employment advancement of APHIV. Fifth, sustainability, through robust post-fellowship systems and continued mentoring support, was emphasized by supervisors and fellows as crucial for supporting APHIV in transitioning to independent living. This study highlights the pivotal role of fellows and the bi-directional power of peer mentorships in addressing the multilevel factors that enhance outcomes for APHIV. By providing knowledge and empathy to their peers and serving as credible role models with lived experience of HIV, fellows within the I'mPossible fellowship exemplify a successful DSD model incorporating the three essential attributes of peer support: informational, emotional, and affirmative support. While these findings underscore the importance of integrating peer-led interventions into HIV care frameworks to support youth with HIV, this also reframes youth as active agents of change, recognizing their capacity for empowerment and meaningful societal contribution rather than passive recipients of care.
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http://dx.doi.org/10.1101/2025.03.11.25323808 | DOI Listing |
Crit Care Explor
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Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States.
Background: Among childhood cancer survivors, germline rare variants in autosomal dominant cancer susceptibility genes (AD CSGs) could increase subsequent neoplasm (SNs) risks, but risks for rarer SNs and by age at onset are not well understood.
Methods: We pooled the Childhood Cancer Survivor Study and St Jude Lifetime Cohort (median follow-up = 29.7 years, range 7.
Am J Physiol Lung Cell Mol Physiol
September 2025
Division of Immunology, Immunity to Infection & Respiratory Medicine, University of Manchester, United Kingdom.
Biomarkers based on volatile organic compounds (VOCs) measured in human breath have been investigated in a wide range of diseases. However, the excitement surrounding such biomarkers has not yet translated to the discovery of any that are ready for clinical implementation. A lack of standardisation in sampling and analysis has been identified as a key obstacle to the validation of potential biomarkers in in multi-centre studies.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Bioengineering, Stanford University, Stanford, CA 94305.
Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with limited light and extreme cold remains unknown. Using a custom subzero temperature microscope during an Arctic expedition, we present the finding of motility at record-low temperatures in a Eukaryotic cell.
View Article and Find Full Text PDFCNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
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