Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Severe hypertriglyceridemia (HTG) is associated with increased risk of cardiovascular disease and acute pancreatitis. Previously, there were no studies or data available from Pakistan regarding this condition. This study aimed to analyze the trends and prevalence of severe HTG in Pakistan over a 5-year period from 2 healthcare centers.
Methods: A retrospective analysis of laboratory data from 2 major healthcare centers across Pakistan's 4 provinces was conducted. Demographic information and lipid profiles of patients were collected. HTG was categorized as HTG (≥150 mg/dL), mild HTG (150-199), moderate HTG (200-999), severe HTG (1000-1999 mg/dL), and very severe HTG (≥2000 mg/dL).
Results: A study of 552,719 individuals (mean age 45.9 ± 12.6 years, 58.1% males and 41.9% females) revealed that 53.7% (1:2) were hypertriglyceridemic. Severe HTG was observed in 0.3% (1:286) of the population, while very severe HTG was found in 0.1% (1:861). Both severe and very severe HTG were more prevalent in males, individuals aged under 18 years, and those aged 36 to 45 years. Very severe HTG was most prevalent in Khyber Pakhtunkhwa (0.2%). Patients with severe HTG presented with mean triglyceride levels of 1308.2 ± 254.7 mg/dL, while those with very severe HTG showed levels of 3293.0 ± 1889.9 mg/dL.
Conclusion: This study revealed that 53.7% of the population had HTG, with severe and very severe HTG affecting 0.3% and 0.1%, respectively. Males, younger individuals, and residents of Khyber Pakhtunkhwa had higher prevalence. These findings emphasize the need for targeted interventions in high-risk groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jacl.2025.02.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construction of a nomogram for hypertriglyceridemic severe acute pancreatitis that includes metabolic indexes.
Lipids Health Dis
September 2025
Department of Gastroenterology, Weifang People's Hospital, The First Affiliated Hospital of Shandong Second Medical University, 151 Guangwen Street, Weifang, Shandong, 261000, China.
Background: Current scoring systems for hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) severity are few and lack reliability. The present work focused on screening predicting factors for HTG-SAP, then constructing and validating the visualization model of HTG-AP severity by combining relevant metabolic indexes.
Methods: Between January 2020 and December 2024, retrospective clinical information for HTG-AP inpatients from Weifang People's Hospital was examined.
Epidemiology of acute pancreatitis: the influence of age and gender in a regional population.
BMC Gastroenterol
August 2025
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey.
Background: Acute pancreatitis (AP) is a common and potentially severe inflammatory condition of the pancreas with a heterogeneous etiology influenced by geographic, demographic, and lifestyle factors. This study aimed to evaluate the distribution of AP etiologies and their associations with age and sex in a regional cohort from a tertiary center.
Materials And Methods: This retrospective observational study included 445 adult patients hospitalized with a first episode of AP between January 2022 and October 2023.
The Role of Therapeutic Plasma Exchange in Treating Hypertriglyceridemia-Associated Acute Pancreatitis: A Real-World Effectiveness Analysis Using the TriNetX Global Collaborative Network.
J Clin Apher
August 2025
Assistant Professor, Department of Gastroenterology and Hepatology, West Virginia University, Charleston, USA.
Therapeutic plasma exchange (TPE) is used to lower triglyceride levels in patients with severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP). However, evidence supporting the effectiveness of TPE in preventing end-organ damage remains limited. This retrospective cohort study was conducted using the TriNetX database to evaluate adults with acute pancreatitis, triglyceride levels > 1000 mg/dL, and "worrisome criteria", defined as clinical indicators of disease severity such as fever, leukocytosis, elevated lactate, or signs of shock.
View Article and Find Full Text PDFTSH as a novel biomarker for recurrence of hypertriglyceridemia pancreatitis: a clinical predictive tool linking lipid dysregulation to inflammation.
Pancreatology
August 2025
Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China; Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China. Electronic address:
Backgrounds: With the change in dietary patterns, the number of patients suffering from hypertriglyceridemia-induced acute pancreatitis (HTG-AP) has been increasing year by year. HTG-AP patients have a higher likelihood of progressing to severe conditions and exhibit a markedly increased risk of recurrence compared to other etiologies. At present, effective prediction models for the recurrence of HTG-AP need to be established and improved urgently, which is of great significance in improving the prognosis of patients.
View Article and Find Full Text PDFA Clinical and Imaging-based Model for Distinguishing Mild From Moderately Severe/Severe Hypertriglyceridemic Acute Pancreatitis: Development and Validation.
J Comput Assist Tomogr
August 2025
Department of Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Background: Hypertriglyceridemic acute pancreatitis (HTG-AP) is a distinct subtype of acute pancreatitis with a wide spectrum of clinical severity, ranging from mild to moderately severe or severe disease. Timely identification of patients at higher risk is essential for informing early clinical decisions and improving outcomes. However, reliable tools specifically designed to stratify HTG-AP severity remain limited.
View Article and Find Full Text PDF