Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Extracorporeal membrane oxygenation (ECMO) is a life-saving support for patients with severe respiratory or cardiac failure. During ECMO support, the pharmacokinetics of drugs is often affected. Therapeutic drug monitoring of antimicrobial agents ensures drug concentrations remain within the therapeutic range of the pharmacokinetic/pharmacodynamic (PK/PD) target.
Methods: In this study, we describe the pharmacokinetic profile of dalbavancin in an 18-month-old child during ECMO and after ECMO discontinuation.
Results: The noncompartmental analysis revealed a notable impact of ECMO on dalbavancin clearance, estimated to be 2.13 times higher during ECMO than after ECMO discontinuation and accounting for a reduction of 52.32% in terminal half-life (79.13 vs 165.98 hours).
Conclusions: This pharmacokinetic alteration in dalbavancin disposition during ECMO may lead to suboptimal drug exposure, possibly impairing the ability to maintain PK/PD efficacy of dalbavancin over time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/FTD.0000000000001325 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Social connectedness without eye contact: 18- but not 9-month-olds use proximal touch to infer third-party joint attention during observational learning.
Dev Psychol
September 2025
Department of Comparative Cultural Psychology, Max Planck Institute for Evolutionary Anthropology.
Decades of research have highlighted the important role of joint attention in early cultural learning. However, most previous studies focused on a limited range of joint attention settings involving the learner's participation in joint attention, characterized by eye contact and triadic gaze following. This has created an incomplete picture, tending to neglect the diversity in which infants experience social connectedness in their daily lives.
View Article and Find Full Text PDFAssociation between maternal folic acid supplementation in different pregnancy and infant neurobehavioral development at 6 and 18 months.
Eur J Clin Nutr
August 2025
School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Background: It has been proven that periconceptional folic acid (FA) supplementation could prevent neural tube defects. However, FA supplementation during different stages of pregnancy and its association with the neurobehavioral development of offspring remains unclear, particularly the effects of continued FA supplementation during the second and third trimesters. This study aimed to investigate the relationship between maternal FA supplementation at various stages of pregnancy and infant neurobehavioral development.
View Article and Find Full Text PDFEffects of the COVID-19 Lockdowns on Gross Motor and Fine Motor Neurodevelopment in Toddlers.
Acta Paediatr
August 2025
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Aim: To investigate possible differences in neurodevelopment between lockdown-exposed and non-exposed 18-month-old toddlers in Sweden.
Methods: Data were extracted from the prospective NorthPop Birth Cohort Study in Sweden. Neurodevelopment was assessed using the Ages and Stages Questionnaire Third Edition (ASQ-3) and a clinical routine evaluation at the child health care centre for additional validation.
Early-Life Trauma as a Trigger for Developmental Myofascial Dysfunction: A Case Report.
Cureus
July 2025
Department of Orthopaedics, CoRSU Rehabilitation Hospital, Kisubi, UGA.
Skeletal asymmetry is a major, unrecognized contributor to myofascial dysfunction and chronic pain in children and adolescents. myoActivation® is a novel medical intervention for the assessment of skeletal asymmetries and treatment of myofascial chronic pain. The therapeutic component of myoActivation involves a needling technique to release myofascial trigger points and scars.
View Article and Find Full Text PDFRegulating bodily states and emotions: the influence of child and caregiver factors on emotional eating in 18-month-old toddlers.
Appetite
August 2025
Centre for Brain Science, Department of Psychology, University of Essex, Colchester, CO4 3SQ, UK. Electronic address:
Parental feeding practices, child temperament, and poor emotion regulation abilities are central factors associated with Emotional Eating (EE) during childhood (3-10 years). Yet, it is poorly understood how children develop EE behaviours in early life. This experimental study investigated the influences of parental and child factors on early expression of EE behaviours in 18-month-old toddlers (N = 71).
View Article and Find Full Text PDF