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The broad learning system (BLS) is a lightweight neural network known for its efficient learning capabilities; however, it is limited by its reliance on a binary label strategy. Existing label enhancement models primarily focus on increasing the distances between labels from different classes, which inadvertently expands the distance within the same category. For classification tasks, maintaining similarity within the intraclass is essential for ensuring the model's effectiveness. To address this issue, we propose a groupwise label enhancement BLS model that ensures both intraclass similarity and interclass disparity of labels. Specifically, we develop a novel regression target that generalizes existing label enhancement targets in BLS, increasing the distances between labels of different classes while overcoming the constraints imposed by binary labels. Moreover, we design a groupwise constraint to jointly enhance the intraclass similarity and interclass disparity of labels. Additionally, we propose a novel alternating direction method of multipliers-based optimization algorithm to solve our proposed model, ensuring both computational efficiency and theoretical convergence. Experimental results on several public datasets demonstrate the outstanding effectiveness and efficiency of our proposed model compared to other state-of-the-art methods.
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http://dx.doi.org/10.1109/TCYB.2025.3550175 | DOI Listing |
Methods
September 2025
Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang 150081, PR China. Electronic address:
Single-cell surface-enhanced Raman scattering (SERS) has emerged as a powerful tool for precision medicine owing to its label-free detection, ultrasensitivity, and unique molecular fingerprinting. Unlike conventional bulk analysis, it enables detailed characterization of cellular heterogeneity, with particular promise in circulating tumor cell (CTC) identification, tumor microenvironment (TME) metabolic profiling, subcellular imaging, and drug sensitivity assessment. Coupled with microfluidic droplet systems, SERS supports high-throughput single-cell analysis and multiparametric screening, while integration with complementary modalities such as fluorescence microscopy and mass spectrometry enhances temporal and spatial resolution for monitoring live cells.
View Article and Find Full Text PDFExp Cell Res
September 2025
The Department of Hematology, The First Affiliated Hospital of Hainan Medical University, No.31 Longhua Road, Haikou City, Hainan Province, 570000, P.R. China. Electronic address:
Background: Nasopharyngeal carcinoma (NPC) is a kind of tumor disease with high malignant degree. CREPT expression was elevated abnormally in multi-cancers. However, the role and regulatory mechanism of CREPT in NPC remains unknown.
View Article and Find Full Text PDFBiochim Biophys Acta Biomembr
September 2025
Instituto de Física, Universidade Federal de Goiás, Goiânia, GO, Brazil. Electronic address:
Three antileishmanial compounds incorporating a butylated hydroxytoluene (BHT) moiety and an acrylate-based Michael acceptor scaffold were rationally designed from the lead structures LQFM064 and LQFM332, which feature a chalcone-derived core. Their activities against Leishmania (L.) amazonensis were evaluated.
View Article and Find Full Text PDFIEEE Trans Cybern
September 2025
Sleep is essential for maintaining human health and quality of life. Analyzing physiological signals during sleep is critical in assessing sleep quality and diagnosing sleep disorders. However, manual diagnoses by clinicians are time-intensive and subjective.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
September 2025
Unsupervised visible-infrared person reidentification (UVI-ReID) has recently gained great attention due to its potential for enhancing human detection in diverse environments without labeling. Previous methods utilize intramodality clustering and cross-modality feature matching to achieve UVI-ReID. However, there exist two challenges: 1) noisy pseudo-labels might be generated in the clustering process and 2) the cross-modality feature alignment via matching the marginal distribution of visible and infrared modalities may misalign the different identities from the two modalities.
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