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Cerebellopontine (CP) angle epidermoid cysts are rare, benign, slow-growing intracranial lesions that arise from ectodermal inclusions during embryogenesis. They often present with symptoms caused by compression of adjacent structures, with trigeminal neuralgia being an uncommon presentation. A 19-year-old female presented with a 1-month history of tingling sensation on the right side of her face. MRI of the brain revealed an extra-axial cystic lesion at the right CP angle extending into the ambient cistern. The lesion appeared hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging, and dirty hyperintense on FLAIR, with diffusion restriction on DWI and no blooming on SWI. It caused a mass effect with compression of the right pons and trigeminal nerve. The patient underwent microsurgical resection of the cyst, and histopathological findings confirmed the diagnosis of an epidermoid cyst. Postoperatively, the patient showed symptomatic improvement and was advised long-term follow-up. This case emphasizes the importance of advanced imaging in diagnosing rare intracranial lesions and highlights surgical resection as an effective treatment for CP angle epidermoid cysts presenting with atypical symptoms.
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http://dx.doi.org/10.1016/j.radcr.2025.01.076 | DOI Listing |
Int J Biol Macromol
September 2025
School of Physics, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. Electronic address:
Keratins represent an important class of sulfur-rich structural proteins. In this study, the pressure response of α-keratin, extracted from sheep wool, was investigated using Raman spectroscopy up to 4 GPa. A non-polar liquid (a Fluorinert™ FC70/77 mixture) served as the Pressure Transmitting Medium (PTM) in a Diamond Anvil Cell (DAC).
View Article and Find Full Text PDFSurg Neurol Int
July 2025
Department of Neurosurgery, University Hospital Ghent, Ghent, Belgium.
Background: Epidermoid cysts are slow-growing, rare congenital lesions. They are most seen in the cerebellopontine angle, fourth ventricle, or parasellar regions. Patients typically become symptomatic between 20- and 40 years of age.
View Article and Find Full Text PDFNo Shinkei Geka
July 2025
Department of Neurosurgery, Tokyo Medical University.
Intracranial epidermoid cysts are congenital benign tumors; however, there is a long-term risk of recurrence if the tumor capsule is left behind perioperatively. Additionally, in cerebellopontine angle surgery, in which cranial nerves and blood vessels are densely concentrated, cranial nerve functions must be preserved besides radical removal of the tumor capsule. Particularly, the optimal surgical field should be obtained under direct visualization to avoid cranial nerve damage due to manipulation over cranial nerves and leaving the tumor behind in the blind spot of the surgical field.
View Article and Find Full Text PDFNo Shinkei Geka
July 2025
Department of Neurosurgery, Tokyo Medical University.
Cerebellopontine angle tumors are rare, and surgeries for these tumors are challenging. Vestibular schwannomas, which account for 70-80% of cerebellopontine angle tumors, are managed by surgery, stereotactic radiosurgery or radiotherapy, and watchful observation. Surgery for vestibular schwannoma aims for maximal tumor resection while preserving facial and/or hearing function through strict intraoperative neuromonitoring.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Otolaryngology, Yusuf al-Azma Hospital, Military Service Administration (MSA) Research Center, G763+J9M, Damascus, Syria.
Introduction: Cholesteatoma is a destructive lesion of keratinizing squamous epithelium in the temporal bone. Its indolent progression often delays diagnosis, leading to osteolytic erosion and temporal bone defects.
Case Presentation: A 20-year-old Syrian male presented with progressive left-sided postauricular swelling, headache, fatigue, and hearing loss, which had recurred intermittently over the past two years.