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Oral disorders are major global health issues, affecting 3.5 billion people and imposing significant economic burdens. This study analyzed the distribution and trends of oral disorder burden globally and in China from 1990 to 2021, aiming to inform resource allocation and prevention strategies. Data from the Global Burden of Disease (GBD) 2021 database were used to evaluate the incidence, prevalence, and years lived with disability (YLDs) of oral disorders. All statistical analyses and data visualizations were conducted using R. In 2021, the burden of oral disorders in China accounted for a significant proportion of the global burden. The incidence, prevalence, and YLDs increased by 15.49%, 52.44%, and 86.86% respectively compared with 1990. The global burden also showed an upward trend during the same period. The relevant indicators in China are at a relatively low level, and disparities were observed among regions with different sociodemographic indices (SDI). Oral disorder burden is on the rise globally, with females, children, adolescents, and the elderly being the key affected groups. Regions with middle SDI bear a heavier burden. This study provides a scientific basis for the formulation of relevant policies and emphasizes the necessity of interventions for specific groups.
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http://dx.doi.org/10.1038/s41598-025-94899-x | DOI Listing |
Can Vet J
September 2025
Alberta Beef Health Solutions, PO Box 307, Picture Butte, Alberta T0K 1V0 CANADA (Brookhart, Dimmers); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T3R 1J3 CANADA (Goldsmith, Janzen, Olchowy, Morrison, Zachar, Remnant. Rogers, Waine); Veterinary Biomedical Sciences, Wester
Over 1200 heavy feedlot cattle presented with severe tongue lesions during a 7-month interval. Review of the literature and discussions with colleagues revealed previous similar outbreaks had occurred in Canada and the USA, with extensive investigations conducted and no cause identified. In the current outbreak, examination of the environment, feed, water, cattle behavior, and husbandry systems were conducted, as well as diagnostic testing including necropsy, histopathology, bacteriology, virology, and toxicology.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Background: Osteoporosis (OP) is a chronic, systemic skeletal disorder characterized by progressive bone loss and microarchitectural deterioration, which increases fracture susceptibility and presents a challenging set of global healthcare problems. Current pharmacological interventions are limited by adverse effects, high costs, and insufficient long-term efficacy. Here, we identify snow crab shell-derived polypeptides (SCSP) as a potent osteoprotective agent.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Neurology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by abnormal megakaryocyte proliferation and a markedly elevated platelet count, which predisposes patients to thrombotic or hemorrhagic events. Approximately 50%-60% of ET patients harbor a JAK2 V617F mutation. This mutation drives constitutive JAK kinase activation, promoting megakaryocyte proliferation and platelet production, while potentially activating inflammatory pathways and damaging vascular endothelium.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
Information Sciences and Technology, George Mason University, Fairfax, VA 22030, USA.
Background: Herein, we report on the initial development, progress, and future plans for an autonomous artificial intelligence (AI) system designed to manage major depressive disorder (MDD). The system is a web-based, patient-facing conversational AI that collects medical history, provides presumed diagnosis, recommends treatment, and coordinates care for patients with MDD.
Methods: The system includes seven components, five of which are complete and two are in development.
Ned Tijdschr Tandheelkd
September 2025
The Department of Oral and Maxillofacial Surgery, University Medical Center Groningen (UMCG), The Netherlands.
Systemic auto-immune diseases are relatively common. This article describes the oral manifestations of disorders that might be seen in patients with the most prevalent auto-immune diseases, specifically rheumatoid arthritis, systemic lupus erythematosus and Sjögren's disease. The article gives guidelines for dentists and other carers within the oral care system for this category of patients.
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