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Federated learning is a distributed machine learning approach designed to tackle the problems of data silos and the security of raw data. Nevertheless, it remains susceptible to privacy leakage risks and aggregation server tampering attacks. Current privacy-preserving methods often involve significant computational and communication overheads, which can be challenging in resource-limited settings, hindering their practical application. To overcome these obstacles, this article proposes an efficient secure aggregation scheme based on secret sharing-GVSA. GVSA safeguards the privacy of local models through a masking technique and improves the system's resilience to user dropouts by utilizing secret sharing. Furthermore, GVSA implements a dual aggregation approach and incorporates lightweight validation tags to verify the accuracy of the aggregation results. By adopting a grouping strategy, GVSA effectively minimizes the computational burden on both users and the server, making it well-suited for resource-constrained environments. We compare GVSA with leading existing methods and assess its performance through various experimental setups. Experimental results demonstrate that GVSA maintains high security while effectively preserving model accuracy. Compared to FedAvg, GVSA incurs only approximately 7% additional computational overhead. Furthermore, compared to other secure aggregation schemes with the same security level, GVSA achieves approximately a 2.3× improvement in training speed.
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http://dx.doi.org/10.1038/s41598-025-94478-0 | DOI Listing |
Neural Netw
September 2025
College of Information Science, North China University of Technology, Beijing, China. Electronic address:
Personalized Federated Learning (pFL) has received extensive attentions, due to its ability to effectively process non-IID data distributed among different clients. However, most of the existing pFL methods focus on the collaboration between global and local models to enrich the personalization process, but ignoring a lot of valuable historical information, which represents the unique learning trajectory of each client. In this paper, we propose a pFL method called FedLFH, which introduces a tracking variable that allows each client to preserve historical information to facilitate personalization.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Information Systems and Cybersecurity, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, United States, 1 (210) 458-6300.
Background: Adverse drug reactions (ADR) present significant challenges in health care, where early prevention is vital for effective treatment and patient safety. Traditional supervised learning methods struggle to address heterogeneous health care data due to their unstructured nature, regulatory constraints, and restricted access to sensitive personal identifiable information.
Objective: This review aims to explore the potential of federated learning (FL) combined with natural language processing and large language models (LLMs) to enhance ADR prediction.
RSC Med Chem
August 2025
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University 4.5 Km the Ring Road Ismailia 41522 Egypt.
Protein kinases are central regulators of cell signaling and play pivotal roles in a wide array of diseases, most notably cancer and autoimmune disorders. The clinical success of kinase inhibitors-such as imatinib and osimertinib-has firmly established kinases as valuable drug targets. However, the development of selective, potent inhibitors remains challenging due to the conserved nature of the ATP-binding site, off-target effects, resistance mutations, and patient-specific variability.
View Article and Find Full Text PDFStat Biosci
August 2024
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Large-scale genomics data combined with Electronic Health Records (EHRs) illuminate the path towards personalized disease management and enhanced medical interventions. However, the absence of "gold standard" disease labels makes the development of machine learning models a challenging task. Additionally, imbalances in demographic representation within datasets compromise the development of unbiased healthcare solutions.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Early diagnosis of Parkinson's disease (PD) is crucial for timely treatment and disease management. Recent studies link PD to impaired facial muscle control, manifesting as "masked face" symptoms, offering a novel diagnostic approach through facial expression analysis. However, data privacy concerns and legal restrictions have resulted in significant "data silos", hindering data sharing and limiting the accuracy and generalizability of existing diagnostic models due to small, localized datasets.
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