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Antiferromagnetic spin fluctuations are the most promising candidate as the pairing glue of high critical temperature (T) superconductivity in cuprates. However, many-body states and intertwined orders have made it difficult to determine how electrons couple with fluctuating spins to form Cooper pairs. Recent experimental and theoretical studies have suggested spin fluctuation-driven quasiparticle band folding, but the relationship between the resultant Fermi pockets and superconductivity remains unclear. Here, using angle-resolved photoemission spectroscopy and numerical simulations, we show a proportional relationship between T and the quasiparticle weight of the incipient hole pocket near the nodal point in electron-doped PrLaCeCuO. Through complementary muon spin spectroscopy measurements, we uncover that the hole pocket forms only in the regime of the fluctuating antiferromagnetic ground state around a presumed quantum critical point. Our observations highlight the significance of the electron-spin fluctuation interaction in enhancing the hole pocket and consequently driving superconductivity.
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http://dx.doi.org/10.1038/s41467-025-57942-z | DOI Listing |
Phys Rev Lett
June 2025
Lanzhou University, School of Physical Science and Technology, Key Laboratory of Quantum Theory and Applications of MoE, Lanzhou 730000, China.
The complex interplay between superconductivity, nematicity, and magnetism in iron-based superconductors remains a significant challenge in understanding its high-temperature superconductivity. Despite that numerous experiments aim at revealing the underlying mechanisms for superconductivity and nematicity by varying multiple tuning parameters, the inherent entanglement of these parameters complicates the isolation of the fundamental factors that drive the transitions. Here, by introducing a novel hydrothermal treatment to FeSe, we are able to effectively reduce interstitial Fe without altering the crystal structure and magnetic properties.
View Article and Find Full Text PDFDrug Chem Toxicol
July 2025
Department of Zoology, Division of Cancer Informatics, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
A myriad of therapeutic candidates targeting SARS-CoV-2 have entered clinical trials; however, the ongoing challenges in SARS-CoV-2 drug discovery, such as adverse effects associated with some therapeutic candidates, necessitate continuous efforts to identify novel therapeutic targets and strategies. This study leverages integrated approaches, encompassing ensemble docking, molecular dynamics (MD) simulations, dynamic unbinding (DUck), and ADMET predictions, to identify novel saquinavir-related antiviral inhibitors targeting the catalytic dyad and oxyanion-hole loop of the SARS-CoV-2 main protease (Mpro). From a library of 33 saquinavir-related analogs, ensemble docking identified three high-affinity ligands ( ≤ -9.
View Article and Find Full Text PDFNPJ Quantum Mater
July 2025
Institute of Solid State Physics, TU Wien, Vienna, Austria.
Following the successful prediction of the superconducting phase diagram for infinite-layer nickelates, here we calculate the superconducting vs. the number of layers for finite-layer nickelates using the dynamical vertex approximation. To this end, we start with density functional theory, and include local correlations non-perturbatively by dynamical mean-field theory for = 2-7.
View Article and Find Full Text PDFJ Med Chem
July 2025
State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Fluorination is common in drug design and may significantly enhance bioactivity, although the underlying mechanism is not elucidated. We noticed a coexisting interaction pattern, viz., F···H and F···O/N/S interactions between organofluorines and protein binding pockets via fluorine atoms.
View Article and Find Full Text PDFBioorg Chem
August 2025
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Monoacylglycerol lipase (MAGL) represents a key enzyme in the regulation of the endocannabinoid system and arachidonic acid signaling, emerging as a promising target for the treatment of inflammation, neurodegeneration, and cancer. Herein, we report the design, synthesis, and biological evaluation of a novel series of o-hydroxyanilide derivatives as reversible MAGL inhibitors. Starting from a known salicylketoxime scaffold, we introduced strategic modifications to reduce lipophilicity and enhance selectivity and potency.
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