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The inconsistency and disparities in existing functional training definitions have led to confusion when explaining the concept and its potential. The wide range of interpretations suggests that any training approach could be deemed functional, thereby diminishing the significance of the term and significantly limiting its understanding and application. Thus, this paper aimed to develop the first consensual definition of functional training using an international e-Delphi method. From a panel of 31 experts initially selected, 13 participated in the consensus. The panel presented the following definition: . However, redundancy of the functional training definition emerged as a relevant consideration for this conceptual and methodological advancement, and a proposal to avoid the distinction between functional training and the general concept of training was presented (i.e., no real use of functional training as a concept). It was proposed that a training program or regimen could be analyzed based on a continuum of functionality, which could support further developments in this topic.
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http://dx.doi.org/10.1080/02640414.2025.2477393 | DOI Listing |
Hypertension
September 2025
Department of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu (Z.W.).
Background: Early-onset preeclampsia poses significant risks to maternal and fetal health, necessitating a deeper understanding of its molecular mechanisms and effective therapeutic strategies.
Methods: Utilizing data from genome-wide association study and Mendelian randomization analysis, we investigated the relationship between mitochondrial DNA copy number and preeclampsia. Transcriptome sequencing, in vitro experiments, and animal studies were conducted to explore the roles of SENP3 and SETD7 in preeclampsia pathogenesis.
Br J Health Psychol
September 2025
Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Manchester, UK.
Objective: This study applied the Theoretical Domains Framework (TDF) to explore the barriers and enablers to optimizing post-operative pain management and supporting safe opioid use from the perspectives of both patients and health care professionals, applying the Theoretical Domains Framework (TDF).
Design: Experience-based co-design (EBCD) qualitative study.
Methods: In the initial phase of the EBCD approach, focus groups were conducted comprising 20 participants, including 8 patients and 12 health care professionals involved in post-operative care.
Antioxid Redox Signal
September 2025
Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis. The relationship between SIC and protein acetylation, particularly the balance between acetylation and deacetylation in cardiomyocyte subcellular structures, as well as how nuclear-mitochondrial coordination maintains standard antioxidant stress capacity, remains unclear. This study focused on exploring the nuclear-mitochondrial regulatory mechanisms formed by the interplay of Sirtuin 3 (SIRT3) and Forkhead box O3a (FOXO3a).
View Article and Find Full Text PDFChild Care Health Dev
September 2025
Department of Behavioral Sciences and Learning, Linköping University, Linköping, Sweden.
Objective: To describe the self-report instruments used to measure well-being in children with disabilities, investigate their psychometric quality, cognitive accessibility and alignment with Keyes's operationalization of well-being, including emotional, psychological and social aspects.
Methods: MEDLINE, ProQuest, PubMed and CINAHL were searched for articles published from 2011 to March 2023, identifying 724 studies. Synonyms provided by thesaurus on the main constructs: 'children', 'measure', 'disability' and 'mental health' were employed in the search strategy.
Plant Cell Environ
September 2025
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry of the Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, China.
Drought stress dynamically reprograms specialised metabolism in medicinal plants. However, the transcriptional regulatory modules governing stress-adaptive metabolite synthesis remain poorly characterised. Here, we identified SbMYB8 as a drought-responsive transcription factor showing nuclear localisation and dose-dependent induction under drought in Scutellaria baicalensis.
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