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http://dx.doi.org/10.1016/j.ctarc.2025.100873 | DOI Listing |
BMJ Open
September 2025
Salisbury NHS Foundation Trust, Salisbury, UK.
Introduction: Difficulty with walking can lead to reduced quality of life for people with Parkinson's disease (pwPD); improving walking is considered a treatment priority. Drug therapies can control PD symptoms; however, pwPD often still experience mobility problems.Functional electrical stimulation (FES) induces movement in weak muscles via external electrical stimulation.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
AMR & HCAI Division, UK Health Security Agency, London, UK.
Background: Species of the (Bcc) have been implicated in multiple nosocomial outbreaks linked to contaminated water-based products, including liquid soaps, mouthwash, and other non-alcoholic aqueous solutions.
Objective: We describe two substantial healthcare-associated outbreaks of Bcc ( and ) in the United Kingdom and Ireland associated with contaminated products. We highlight the challenges during investigation and mitigation, and provide recommendations.
In Vivo
August 2025
Department of Anatomy, School of Medicine, Chosun University, Gwang-ju, Republic of Korea
Background/aim: The middle cerebral artery occlusion (MCAO) model is widely used to study stroke pathobiology. Dexmedetomidine (DEX) has demonstrated neuroprotective effects in ischemic brain models. Previous studies have shown that nuclear factor erythroid 2-related factor 2 (Nrf2) expression changes in the parietal cortex, which is supplied by the middle cerebral artery, after ischemic injury.
View Article and Find Full Text PDFAliment Pharmacol Ther
August 2025
Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italy.
Background & Aims: Despite recommendations from scientific societies that hepatitis B immunoglobulin (HBIG) can be safely discontinued, centres across Europe continue to use the combination nucleoside analogues (NAs) plus HBIG for long-term prophylaxis against hepatitis B virus (HBV) recurrence after liver transplant (LT). The aim of this study was to evaluate the safety of HBIG withdrawal in a cohort of LT recipients on long-term HBIG+NAs.
Methods: All patients under third-generation NAs + HBIG and who adhered to the INSIGHT-B protocol were followed up after HBIG withdrawal, in a multicentre, prospective, Italian cohort study, to evaluate the risk of HBV reactivation.
BMC Neurol
August 2025
Department of neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China.
Background: Vertebrobasilar dolichoectasia (VBD) is a rare cerebrovascular disorder. The natural history of patients with VBD is generally poor, and current treatments do not appear to provide significant clinical benefit. Therefore, understanding the underlying mechanisms of VBD and implementing appropriate strategies in advance are particularly important.
View Article and Find Full Text PDF