Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The Tibetan sheep is a typical hypoxia-tolerant mammal, which lives on the plateau, at an altitude of between 2500 and 5000 m above sea level; the study of its hypoxic adaptation mechanism provides a reference for exploring the hypoxic adaptation mechanism of other animals. To grope for the genetic mechanism of adaptation to the hypoxic environment at the transcriptional level in Tibetan sheep testicular tissue, and to identify candidate genes and key pathways related to sheep adaptation, histological observation of testicular tissues from two sheep breeds was carried out using haematoxylin-eosin (HE) conventional staining. A total of 103 differentially expressed genes (DEGs) were authenticated in high altitude Tibetan sheep (ZYH) and low altitude Tibetan sheep (ZYM) by RNA sequencing technology (RNA-Seq), which included 50 up-regulated genes and 53 down-regulated genes. Functional analyses revealed several terms and pathways that were closely related to testis adaptation to the plateau. Several genes (including GGT5, AGTR2, EDN1, LPAR3, CYP2C19, IGFBP3, APOC3 and PKC1) were remarkably enriched in several pathways and terms, which may impact the Plateau adaptability of sheep by adjusting its reproductive activity and sexual maturation, and protecting Sertoli cells, various spermatocytes, and spermatogenesis processes. The results make a reasonable case for a better understanding of the molecular mechanisms of adaptation to altitude in sheep.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/rda.70037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds.
Front Genet
August 2025
College of Poultry Production and Management, TANUVAS, Hosur, India.
Background: India's indigenous sheep breeds have evolved under extreme and diverse agro-ecological pressures, yet the genomic basis of their resilience and local adaptation remains poorly understood.
Method: This study combines genomic inbreeding estimates, runs of homozygosity (ROH), population structure analyses, and composite selection scans to investigate three native Indian breeds-Changthangi, Deccani, and Garole-within a panel of nine breeds that also includes populations from Africa (Ethiopian Menz), East and South Asia (Tibetan, Chinese Merino, Bangladesh Garole, Bangladesh East), and Europe (Suffolk).
Results: ROH and heterozygosity estimates revealed strong contrasts: Bangladesh East sheep exhibited high genomic inbreeding (F≈14.
Grazing system and body weight of Tibetan sheep influence biomass allocation and decomposition in alpine meadows.
J Environ Manage
September 2025
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China,
Grazing affects the allocation of aboveground biomass (AGB), and decomposition of litter and dung, thereby regulating material flow in grassland ecosystems. However, the combined effects of grazing system (GS) and body weight (BW) on biomass allocation remain unclear. This study had conducted a two-year experiment in an alpine meadow of Qinghai-Tibetan Plateau (QTP), in order to examine the effects of two GS (continuous grazing - CG, and rotational grazing - RG) and three BWs of Tibetan sheep (23.
View Article and Find Full Text PDFGenome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes.
Front Vet Sci
August 2025
Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Altitude adaptation is a complex process involving multiple physiological and biochemical responses to hypoxia and other environmental stresses. In-depth genetic analysis of Tibetan sheep, which exhibit significant adaptations to high-altitude hypoxia, promises to elucidate hypoxia-tolerance mechanisms in plateau animals. Here, we conducted a genome-wide selection scan on three Tibetan sheep populations: low-altitude Tao (TS; 2887 m), medium-altitude Tianjun white (WT; 3331 m), and high-altitude Huoerba (HB; 4614 m).
View Article and Find Full Text PDFMulti-omics analysis reveals host-microbe interactions driving divergent energy allocation strategies in Tibetan sheep under cold-season feeding regimes.
J Anim Sci Biotechnol
September 2025
Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810008, China.
Background: As an indigenous livestock species on the Tibetan Plateau, Tibetan sheep exhibit remarkable adaptability to low temperatures and nutrient-scarce environments. During the cold season, Tibetan sheep are typically managed under two feeding regimes: barn feeding (BF) and traditional grazing (TG). However, the molecular mechanisms underlying their adaptation to these distinct management strategies remain unclear.
View Article and Find Full Text PDFMolecular Genetic Basis of Reproductive Fitness in Tibetan Sheep on the Qinghai-Tibet Plateau.
Genes (Basel)
July 2025
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
: Complete environmental adaptation requires both survival and reproductive success. The hypoxic Qinghai-Tibet Plateau (>3000 m) challenges reproduction in indigenous species. Tibetan sheep, a key plateau-adapted breed, possess remarkable hypoxic tolerance, yet the genetic basis of their reproductive success remains poorly understood.
View Article and Find Full Text PDF