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This review provides a general overview of collagen structure, biosynthesis, and biological properties, with a particular focus on marine collagen sources, especially fisheries discards and by-catches. Additionally, well-documented applications of collagen are presented, with special emphasis not only on its final use but also on the processes enabling sustainable and safe recovery from materials that would otherwise go to waste. Particular attention is given to the extraction process, highlighting key aspects essential for the industrialization of fish sidestreams, such as hygiene standards, adherence to good manufacturing practices, and ensuring minimal environmental impact. In this context, the EcoeFISHent projects have provided valuable insights, aiming to create replicable, systemic, and sustainable territorial clusters based on a multi-circular economy and industrial symbiosis. The main goal of this project is to increase the monetary income of certain categories, such as fishery and aquaculture activities, through the valorization of underutilized biomass.
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http://dx.doi.org/10.1007/s10126-025-10438-9 | DOI Listing |
Food Funct
September 2025
Department of Animal Nutrition, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Sheep milk has gained increasing attention for its compositional similarity to human milk and its abundance of bioactive compounds with nutritional and therapeutic potential. It is rich in proteins, essential fatty acids, vitamins, minerals, immunoglobulins, and hormones, as well as peptides and oligosaccharides with antiviral, antibacterial, anti-inflammatory, and immune-modulatory effects. Despite these benefits, the literature remains fragmented, with limited integration of data on the mechanisms by which these components influence health outcomes, and few comprehensive comparisons with other mammalian milks.
View Article and Find Full Text PDFInt J Pharm
September 2025
Department of Pharmaceutical Sciences, Via del Liceo 1, 06123 Perugia, Italy. Electronic address:
Indole-3-carboxaldehyde (I3A), a microbial tryptophan metabolite, exhibits significant immunomodulatory activity at the host-microbial interface. However, its rapid transformation into metabolites like indole-3-carboxylic acid (I3CA) raises questions about their therapeutic potential. This study aimed to evaluate the pharmacological contributions of I3CA through the development of a proper delivery strategy.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, PR China. Electronic address:
Li/CF primary batteries are renowned for their exceptional energy density, yet their practical deployment is hindered by the inherently sluggish kinetics of the CF cathode. This study addresses this limitation by incorporating selenium (Se) into CF (denoted as CF/Se) via a facile low-temperature thermal treatment, significantly enhancing its electrochemical performance. Comprehensive spectroscopic and electrochemical analyses reveal that Se doping induces the formation of CSe bonds, which promote semi-ionic CF bonding, thereby accelerating Li diffusion and reducing charge transfer resistance.
View Article and Find Full Text PDFJ Biomech
September 2025
Division of Vascular Surgery, Stanford University, Stanford, 94305, CA, USA.
The helical morphology of Type B aortic dissections (TBAD) represents a potentially important geometric biomarker that may influence dissection progression. While three-dimensional surface-based quantification methods provide accurate TBAD helicity assessment, their clinical adoption remains limited by significant processing time. We developed and validated a clinically practical centerline-based helicity quantification method using routine imaging software (TeraRecon) against an extensively validated surface-based method (SimVascular).
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
Genetic code expansion (GCE) technology has primarily been devoted to the introduction of noncanonical amino acids (ncAAs) into ribosomally synthesized proteins or peptides. Its potential for modifying nonribosomal natural products remains unexplored. In this study, we introduce a novel strategy that integrates GCE with the directed evolution of cyclodipeptide synthase (CDPS) to engineer a new class of CDPSs capable of biosynthesizing cyclodipeptides containing ncAAs.
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