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Article Abstract
The Canary Islands, a region with high asthma prevalence, are frequently exposed to Saharan Dust Intrusions (SDIs), as are a wide range of countries in Europe. Alpha-1 antitrypsin ( gene) regulates the airway's inflammatory response. This study analyzed the combined effect of SDI exposure and variants on bacterial/fungal DNA concentrations in saliva and pharyngeal samples from asthmatic patients. Bacterial and fungal DNAs were quantified by qPCR in 211 asthmatic patients (GEMAS study), grouped based on their exposure to daily PM concentrations. Associations between SDI exposure, microbial DNA concentrations, and nine variants in were tested using linear regression models adjusted for confounders. The ratio between bacterial and fungal DNA was similar in saliva and pharyngeal samples. SDI exposure for 1-3 days was enough to observe significant microbial DNA change. Increased bacterial DNA concentration was detected when SDI exposure occurred 4-10 days prior to sampling, while exposure between days 1 and 3 led to a reduction in the fungal DNA concentration. The T-allele of SNV rs2854254 prevented the increase in the bacterial/fungal DNA ratio in pharyngeal samples after SDI exposure. The bacterial/fungal DNA ratio represents a potential tool to monitor changes in the microbiome of asthmatic patients.
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| http://dx.doi.org/10.3390/ijms26052158 | DOI Listing |
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