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Developing and implementing effective surveillance programs for infectious diseases (ID) and antimicrobial resistance (AMR) requires the integration of information across relevant disciplines and sectors. Yet, establishing and sustaining collaboration at each step of the surveillance process, and modalities to translate integrated surveillance results into actions, are not well understood. This systematic review was designed to map and explore peer-reviewed tools that were either designed or used for evaluation of integrated surveillance systems for ID or AMR, and to identify the limitations of these tools and remaining methodological or knowledge gaps. A systematic search was conducted using keywords related to: "Evaluation", "Surveillance" and "One Health" in four databases (Medline, Embase, Web of Science and CAB abstract) up to the 28th of October 2022. Articles were selected if they presented an evaluation tool for integrated surveillance systems for ID or AMR (methodological study) or an application of such a tool (case study). All selected articles went through a quality check using the MetaQAT tool. Of 25 articles retrieved, 13 presented a methodological study, while 12 described a case study. Three main types of evaluation were identified through 17 tools: theoretical, process and impact evaluations. Both methodological and case study papers predominantly considered organizational and operational aspects in their evaluation. Although costs and/or impacts were discussed in some case studies, only one article reported an economic impact analysis. Evaluation of One Health integration and multisectoral collaboration was included in four methodological and four case study articles. One major challenge identified in this systematic review is the lack of clear guidance and standardized criteria for the comprehensive evaluation of complex integrated surveillance systems. To overcome this, it is essential to develop, validate, and apply methodologies adapted to these evaluation needs.
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http://dx.doi.org/10.1016/j.onehlt.2025.100995 | DOI Listing |
Nat Rev Urol
September 2025
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Low-grade non-muscle invasive bladder cancer is a specific category of bladder cancer with a favourable prognosis; however, its management presents several challenges. The risk of stage progression is very low, but approximately half of patients will experience recurrence within the first 5 years after diagnosis. This high propensity for recurrence, coupled with the threat of progression, mandates ongoing surveillance.
View Article and Find Full Text PDFCommun Med (Lond)
September 2025
Department of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surprising that to date, the extent of this complexity has not been systematically explored in high-burden countries of sub-Saharan Africa, especially in the reservoir of asymptomatic infections in all ages, which sustains transmission.
Methods: Here we take a metagenomic lens to these infections by sampling variable blood volumes from 188 afebrile residents living in high, seasonal transmission in Northern Sahelian Ghana.
Thorax
September 2025
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Introduction: Breathlessness is a common cause of hospital admission globally and is associated with high mortality, particularly in low-income countries. In sub-Saharan Africa, there is a paucity of data on breathlessness, with existing data focused on individual diseases. There is a need for patient-centred approaches to understand interactions between multiple conditions to address population needs and inform health system responses.
View Article and Find Full Text PDFJ Neurosci
September 2025
College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China
Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism that degrades transcripts with premature termination codons (PTCs) and finetunes gene expression by targeting RNA transcripts with other NMD inducing features. This study demonstrates that conditional knockout of , a key NMD component, in oligodendrocyte lineage cells disrupts the degradation of PTC-containing transcripts, including aberrant variants of the RNA-binding protein The loss of SMG5 in both sexes of mice impaired oligodendrocyte differentiation, reduced myelin gene expression, and led to thinner myelin sheaths and compromised motor function in mice. Mechanistically, HNRNPL was shown to regulate the alternative splicing of myelin-associated genes and , and promote oligodendrocyte differentiation.
View Article and Find Full Text PDFPrim Care Diabetes
September 2025
Department of Health Sciences and Human Performance Department, College of Natural and Health Sciences, The University of Tampa, Tamp, FL, USA. Electronic address:
Aim: This study aims to compare the weekly resistance training (RT) frequency between people with diabetes, prediabetes, and without diabetes.
Methods: A total of 536,703 participants from 2017 to 2023 Behavioral Risk Factors Surveillance System were included in the analysis. Unadjusted and adjusted Poisson regression was performed to compare weekly resistance training frequency among participants with different diabetes statuses (without diabetes, prediabetes, and with diabetes).