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Adv Ther
September 2025
Bristol Myers Squibb, Princeton, NJ, 08540, USA.
Background And Objectives: Deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor, demonstrated efficacy across the primary endpoint and all key secondary endpoints in the phase 2 PAISLEY SLE trial in patients with active systemic lupus erythematosus (SLE). Here, we describe 2 phase 3 trials [POETYK SLE-1 (NCT05617677), POETYK SLE-2 (NCT05620407)] which will assess the efficacy and safety of deucravacitinib in patients with active SLE. These phase 3 trials have been designed to replicate the successful elements of the phase 2 trial, including its glucocorticoid-tapering strategy and disease activity adjudication.
View Article and Find Full Text PDFRheumatol Int
September 2025
Department of Physical Medicine and Rehabilitaton, Ankara Bilkent City Hospital, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Türkiye, Turkey.
The Impact of Obesity and Overweight on Rheumatoid Arthritis Patients: Real-World Insights from a Biologic and Targeted Synthetic DMARDs Registry. The management of rheumatoid arthritis (RA) has advanced with biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs). However, obesity, a common comorbidity, impacts treatment and disease progression efficacy.
View Article and Find Full Text PDFObjectives: Azapirone-class drugs are partial 5-HT1A receptor agonists commonly used to treat anxiety disorders. Prior experimental studies have so far demonstrated that these drugs have low potential for dependence and problematic use and are considered safe treatment options compared with benzodiazepines. However, recent evidence suggesting the contrary raises concerns about their safety.
View Article and Find Full Text PDFTransl Anim Sci
July 2025
Department of Animal Sciences, Purdue University, West Lafayette, IN 47906, USA.
Transportation at weaning is an integral component of the American swine industry. However, the long-term effects on growth performance have not been well characterized. Previous research suggests transportation causes weight loss immediately following weaning, but few studies have followed this effect further than 7 d post-weaning, with transport causing decreased body weight in those that have.
View Article and Find Full Text PDFTob Use Insights
September 2025
Institute for Therapy and Health Research, IFT-Nord, Kiel, Germany.
Introduction: Loneliness, a feeling of inadequate social relationships, is associated with behavioural health issues. This study examines the co-occurrence of loneliness and nicotine use (e-cigarettes, cigarettes and waterpipe (WP)) among adolescents aged 9-17 years in Germany.
Methods: Data were derived from the eighth wave of the "Präventionsradar", an annual school-based survey in Germany.