Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
There is a parallel epidemic of atrial fibrillation (AF) and hypertension (HTN) occurring globally. Both AF and HTN are no longer confined to the older population. The pathophysiology of AF related to HTN is complex with many inter-related factors. Hypertension causes hypertrophy of the ventricular musculature, dilatation of atria, elevated intracardiac pressures, atrial and ventricular mechanical dysfunction, abnormal expression of ion channels, dysregulation of the renin-angiotensin-aldosterone system, and the autonomic function. The pathophysiological alterations and structural changes that occur in the atria, including architectural subcellular abnormalities fibrosis, are considered to cause atrial cardiomyopathy (atriopathy) predisposing to AF. In this review, we discuss some relevant and combined basic and translational science data related to HTN leading to atriopathy and AF and possible clinical applications in the treatment and prevention of AF in patients with HTN.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/jce.16632 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Indirect treatment comparison of two pulsed field ablation systems for the treatment of persistent atrial fibrillation.
J Interv Card Electrophysiol
September 2025
Cardiac Ablation Solutions, Medtronic, Minneapolis, MN, USA.
Background: Catheter ablation is beneficial in patients with symptomatic persistent atrial fibrillation (PerAF), and pulsed field ablation (PFA) is a promising energy source to safely and durably create ablation lesions. However, catheter-specific "PFA waveforms and designs" result in effectiveness and safety profiles that are not transferable to other PFA technologies. A head-to-head comparison between the dual-energy, wide-footprint lattice-tip (Sphere-9, Medtronic) and pentaspline PFA catheter (Farawave, Boston Scientific) is not yet available.
View Article and Find Full Text PDFOpportunistic Detection of Atrial Fibrillation in the Emergency Department: Today's Health Care Systems Are Not Prepared to Reap the Benefits.
Ann Emerg Med
September 2025
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
[An incidental atrial fibrillation. Is the best the enemy of good?].
Rev Med Suisse
August 2025
Service de cardiologie, HFR Fribourg - Hôpital cantonal, 1752 Villars-sur-Glâne.
Atrial fibrillation (AF) is common in the elderly and often incidental. While anticoagulation is facilitated by risk-stratification scores, rate versus rhythm-control in the elderly and likely asymptomatic population remain challenging. We report an 80-year-old male with newly diagnosed slow AF, referred for an electrical cardioversion after amiodarone loading.
View Article and Find Full Text PDFHypertrophic Cardiomyopathy: Mechanisms of Pathogenicity.
Biomed Environ Sci
August 2025
Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital Heart Center, Zhengzhou 451464, Henan, China.
Hypertrophic cardiomyopathy (HCM) is a major contributor to cardiovascular diseases (CVD), the leading cause of death globally. HCM can precipitate heart failure (HF) by causing the cardiac tissue to weaken and stretch, thereby impairing its pumping efficiency. Moreover, HCM increases the risk of atrial fibrillation, which in turn elevates the likelihood of thrombus formation and stroke.
View Article and Find Full Text PDFMicro-Embolic Events and Their Clearing in the Brain. A Narrative Review.
Acta Physiol (Oxf)
October 2025
Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Background: The cerebral circulation is continuously challenged by intravascular micrometer-sized particles that become trapped microvascular-emboli. These particles may include micro-thrombi, stiffened erythrocytes, and leukocytes, while also fat particles, air, and microplastics may cause microvascular embolism.
Review Scope: In this narrative review, we discuss these embolization processes and their acute and chronic consequences.