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Background: Day-of-procedure cancelations are a hardship, affecting patients, families, and health care systems. One major cause of cancelations is nil by mouth (nil per os [NPO]) noncompliance. Previous single-center studies show conflicting results regarding risk factors for cancelations. The primary objective of this study was to identify demographic populations with higher-than-predicted rates of NPO noncompliance, as defined by local institutional NPO guidelines. The secondary objective was to determine whether demographic and system risk factors were associated with procedure cancelations due to NPO noncompliance.
Methods: A multicenter retrospective case-control study was conducted of children <18 years of age presenting for elective procedures requiring adherence to local institutional NPO guidelines. Data collected included sociodemographic characteristics (age, sex, race-ethnicity, language of care, and medical insurance type) and systems factors (time of day for the scheduled procedure and communication modalities used to share NPO guidelines). The primary outcome was the occurrence of noncompliance of local institutional NPO guidelines. The secondary outcome was a cancelation of the elective procedure due to NPO noncompliance. A χ2 goodness-of-fit test and multivariable logistic regression were used for statistical analyses.
Results: Among 164,147 pediatric patients across 10 institutions, a total of 1208 instances of NPO noncompliance were identified (0.74%). Of the patients who experienced an NPO noncompliance event, 52% had their procedure delayed to a later time of the day, and 48% had their procedure canceled. Risk factors for NPO noncompliance included being younger than <4 years old, belonging to minority race-ethnicity groups, having Spanish as the primary language of care, and having public health insurance. In the multivariable analysis, the odds of cancelation after an NPO noncompliance event were 46% higher for children whose preprocedure phone call was not answered, 62% higher for children over 4 years old, 80% higher for non-Hispanic African American/Black children, 88% higher for children with public health insurance, and twice as high for procedures scheduled in the afternoon.
Conclusions: This multicenter study identified age, race-ethnicity, language of care, and health insurance type as factors associated with the occurrence of NPO noncompliance. Certain demographic and system risk factors were linked to higher rates of day-of-procedure cancelations due to NPO noncompliance. These findings raise concerns regarding disparities in access to care especially in minority populations already at an increased risk of inadequate health care access. Identifying these risk factors can help drive the development of strategies to address inequities and improve access to health care.
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http://dx.doi.org/10.1213/ANE.0000000000007451 | DOI Listing |
Environ Sci Technol
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
While the cancer genome is well-studied, the nongenetic exposome of cancer remains elusive, particularly for regionally prevalent cancers with poor prognosis. Here, by employing a combined knowledge- and data-driven strategy, we profile the chemical exposome of plasma from 53 healthy controls, 14 esophagitis and 101 esophageal squamous cell carcinoma (ESCC) patients, and 46 esophageal tissues across 12 Chinese provinces, integrating inorganic, endogenous, and exogenous chemicals. We first show that components of the ESCC chemical exposome mediate the relationship between ESCC-related dietary/lifestyle factors and clinic health status indicators.
View Article and Find Full Text PDFJAMA Neurol
September 2025
Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Urology, Center for Health Outcomes Research and Dissemination, University of Washington, Seattle.
Importance: Black individuals have a twofold higher rate of prostate cancer death in the US compared with the average population with prostate cancer. Few guidelines support race-conscious screening practices among at-risk Black individuals.
Objective: To examine structural factors that facilitate or impede access to prostate cancer screening among Black individuals in the US.
Int J Speech Lang Pathol
September 2025
Grampians Health, Ballarat, Australia.
Purpose: Many mealtime interventions have been developed over the past ten years. The effective implementation of such interventions into clinical practice is crucial to improve the swallowing safety and/or mealtime-related quality of life for people living with dysphagia or at risk of malnutrition. This systematic review summarises and critically appraises the literature on implementation of mealtime interventions in inpatient and aged care settings.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
September 2025
Brigham and Women's Hospital, Boston, MA, United States.
Background: Colorectal cancer (CRC) risk models routinely adjust for endoscopic screening because of a) possible confounding with other risk factors and b) possible alteration of natural history of the disease due to adenoma detection and removal.
Methods: In this study, we defined a subject as screen-covered (SC) if a colonoscopy was performed in the past 10 years, and not screen-covered (NSC) otherwise. We created CRC risk models separately for SC and NSC subjects (HRSC, HRNSC) and then obtained a screening-coverage adjusted HR estimate (HRfull) based on a weighted average of ln(HRSC) and ln(HRNSC) with weight equal to the proportion of SC person-time in the NHS population.