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Evaluate the demand, volume, and institutional utilization of an EHR-based platform for health data exchange in a single US academic system. A retrospective review (3/2023-4/2024) spanned 11 hospitals and over 500 outpatient sites. Analytic reports from the Epic Care Everywhere Image Exchange Advanced Platform (Verona, WI) captured inbound (requested internally) and outbound (accessed externally) data volumes, including thumbnails and subsequent reference-quality key image retrievals. Data types were categorized as DICOM or non-DICOM (e.g., JPG, PDF). Counts, retrieval rates, and geographic patterns were analyzed. Inbound data involved 1.6 million patients from 370 external organizations, generating 5% for DICOM and 3% for non-DICOM; 77% of inbound thumbnails originated in-state. From 3/2023 to 4/2024, 1.9 million outbound thumbnails were accessed by 1478 external institutions, with a 78% reference-quality key image retrieval rate. Most outbound thumbnails were non-DICOM (66%); however, overall DICOM retrieval rates (5%) were higher than non-DICOM (3%). In-state institutions retrieved the most thumbnails (1,156,896/59%), whereas out-of-state sites requested more reference-quality key images (1,034,614/67%). Top users included various private and public health sectors. Findings show a growing reliance on EHR-embedded health data exchange. The abundance of inbound non-DICOM underscores interoperability challenges, while high DICOM retrieval rates emphasize clinical importance. Geographic disparities highlight the need for standardized solutions to improve continuity of care. Moreover, the upcoming HTI-2 bill mandates stronger data exchange measures, reinforcing the urgency for scalability. Health data exchange is in high demand as patients increasingly seek care across the US.
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http://dx.doi.org/10.1007/s10278-025-01459-w | DOI Listing |
FocA belongs to the formate-nitrite transporter (FNT) superfamily of pentameric membrane proteins, which translocate small, monovalent anions across the cytoplasmic membrane of bacteria, archaea and certain protists. FocA translocates formate anions or formic acid bidirectionally through a hydrophobic pore present in each protomer. This pore has two highly conserved amino acid residues, threonine 91 and histidine 209 that are proposed to protonate the anion during the translocation process.
View Article and Find Full Text PDFMagn Reson Med
September 2025
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Purpose: Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it will likely impact parameter uncertainty. Here, we analyze the identifiability of two-compartment models used in multi-echo (ME) blood-brain-barrier (BBB)-ASL and evaluate the reliability of the fitted water-transfer rate ).
View Article and Find Full Text PDFAAPS PharmSciTech
September 2025
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
The chimpanzee adenovirus-vectored vaccine developed by the University of Oxford (ChAdOx1 nCoV-19) showed good stability when stored in refrigerator. However, the vaccine manufacturer prefers its transportation in frozen condition. Data regarding the stability of the vaccine after exposure to repeated freezing processes have not been explored yet.
View Article and Find Full Text PDFPerfusion
September 2025
Cardiac Surgery Department, Bristol Royal Children's Hospital, Bristol, UK.
BackgroundDuring cardiopulmonary bypass (CPB), goal-directed perfusion (GDP) seeks to match oxygen delivery to metabolic demand, but the dynamics of oxygen extraction and intraoperative oxygen demand remain poorly understood, especially in paediatric populations. Existing models rely on limited data and assume, for example, a linear relationship between log oxygen demand and temperature.MethodsWe developed GARIX (Global AutoRegressive Integrated model with eXogenous variables and an equilibrium force) to predict minute-by-minute changes in oxygen extraction ratio (OER) using high-resolution intraoperative data.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Faculty of Medicine, The University of Sydney, Sydney, Australia.
Background: Hypertensive disorders of pregnancy (HDP) affect up to 10% of pregnancies and can have adverse short and long-term implications for women and their babies. eHealth interventions include any health service or treatment delivered using the internet and related technology that aims to facilitate, capture, or exchange knowledge. eHealth interventions are increasingly used across many health care settings with improved outcomes.
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