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http://dx.doi.org/10.1016/j.jlb.2025.100286 | DOI Listing |
Cureus
August 2025
Department of Radiotherapy Physics, Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, GBR.
Introduction Stereotactic radiosurgery (SRS) is widely regarded as the standard of care after the resection of brain metastases in order to reduce local cavity recurrence risk. The objective of this study was to explore the reproducibility of published outcomes for patients receiving post-operative stereotactic radiosurgery (cavity SRS) in a National Health Service (NHS) setting for a non-selective series of patients. For our service, the median interval between surgery to cavity SRS (cSRS) is eight weeks, whereas similar timelines have been found to have a deleterious impact on survival in the published literature.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Orthopaedics, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Objective: To comprehensively examine the incidence and mortality of malignant neoplasms of bone and articular cartilage (MNBAC) in China compared with the world, as well as its age-specific patterns and sex disparities.
Methods: The MNBAC burden in China and the world was systematically assessed from 1990 to 2021 based on the Global Burden of Disease 2021, including incidence and mortality data. The estimated annual percentage change was calculated.
Fenugreek seeds ( L.) are known for their impressive range of health benefits, thanks to their diverse array of phytochemicals. These include steroidal sapogenins like diosgenin, alkaloids such as trigonelline, as well as flavonoids, saponins, galactomannans, and polyphenols.
View Article and Find Full Text PDFStat Med
September 2025
Biostatistics and Data Management, Regeneron Pharmaceuticals, Tarrytown, New York, USA.
Typical phase 1 oncology studies identify the maximum tolerated dose as the "optimal" dose for subsequent phases. With the advancement of molecular targeted agents and immunotherapies, however, evaluating two or more doses has become increasingly critical for dose selection. Such evaluation is often done in phase 2 studies in a randomized manner.
View Article and Find Full Text PDFTher Adv Med Oncol
September 2025
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center For Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuannanli 17#, Beijing 100021, China.
Background: Thrombocytopenia is a common hematological toxicity in esophageal cancer (EC) patients receiving radiation therapy.
Objectives: The purpose of this study was to construct and validate a nomogram for predicting the incidence of thrombocytopenia in EC patients receiving radiotherapy.
Design: A retrospective study.