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We propose a reliable and simple approach for dispersion engineering in lithium niobate microring resonators (MRRs). With strong coupling-induced mode hybridization and inverse design method, we overcome the large normal dispersion and achieve broadband frequency comb coverage near 525 nm. We adopt a neural network method in the inverse design, which outperforms the traditional forward design based on manual trial-and-error and intuitive judgment. Our numerical results demonstrate the possibility of generating a visible Kerr soliton microcomb with a bandwidth of 214.4 nm in a single MRR, which holds significant potential for applications in bioimaging and on-chip atomic clocks.
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http://dx.doi.org/10.1364/OL.555498 | DOI Listing |
Ann Med
December 2025
Department of Gynecology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Objective: To evaluate preoperative serum calcium levels and their association with deep infiltrating endometriosis (DIE) in ovarian endometrioma.
Design: A retrospective, observational cohort study.
Participants: A total of 2,557 women who underwent surgery for benign ovarian tumors were initially enrolled.
Angew Chem Int Ed Engl
September 2025
Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, P.R. China.
Porous organic cages (POCs) have emerged as promising porous materials for a wide range of applications. However, their development is often limited by insufficient chemical stability and challenges in systematically functionalization. Herein, we reported the design and synthesis of a tetrazine-based POC (TC1) featuring rigid tetrahedral structure, prepared via a one-pot nucleophilic aromatic substitution reaction.
View Article and Find Full Text PDFACS Chem Biol
September 2025
Institute for Biomedicine and Glycomics, Griffith University, Queensland, 4111 Brisbane, Australia.
Small-molecule metabolic chemical probes are tailored chemical biology tools that are designed to detect and visualize biological processes within a cell or an organism. Nucleoside analogues are a subset of metabolic probes that enable the study of DNA synthesis, proliferation kinetics, and cell cycle progression. However, most available nucleoside analogue probes have been designed for use in mammalian cells, limiting their use in other species, where there are metabolic pathway differences.
View Article and Find Full Text PDFLipids
September 2025
Ecotera Health, Blue Ash, Ohio, USA.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants increasingly implicated in cardiometabolic risk. This study evaluates the association between serum PFAS exposure and lipid dysregulation, focusing on low-density lipoprotein cholesterol (LDL-C), a key cardiovascular risk factor. We analyzed 998 adults from the 2017 to 2020 National Health and Nutrition Examination Survey (NHANES), representing a weighted sample of 240 million US adults.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Iron-the most abundant magnetic brain substance-is essential for many biological processes, including dopamine and myelin synthesis. Quantitative susceptibility mapping (QSM) MRI has recently linked altered subcortical magnetic susceptibility (χ) to schizophrenia. Since χ is increased by iron and decreased by myelin, abnormal levels of either could underlie these QSM differences.
View Article and Find Full Text PDF